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Within the medical specialty of hematology, Hemoglobin D-Punjab, also known as hemoglobin D-Los Angeles, [1] D-North Carolina, D-Portugal, D-Oak Ridge, and D-Chicago, [2] is a hemoglobin variant. It originates from a point mutation in the human β-globin locus and is one of the most common hemoglobin variants worldwide. [ 1 ]
Hemoglobin D (HbD) is a variant of hemoglobin, a protein complex that makes up red blood cells.Based on the locations of the original identification, it has been known by several names such as hemoglobin D-Los Angeles, hemoglobin D-Punjab, [1] D-North Carolina, D-Portugal, D-Oak Ridge, and D-Chicago. [2]
Hemoglobin D/ beta thalassemia: common in the northwestern parts of India and Pakistan (Punjab region). [33] Hemoglobin E/ beta thalassemia: common in Cambodia, Thailand, and parts of India, it is clinically similar to β thalassemia major or β thalassemia intermedia. [34]
Hemoglobin D-Punjab; Hemoglobin E; Hemoglobin Hopkins-2; Hemoglobin Lepore syndrome; Hemoglobin O; Hemoglobin O-Arab; Hemoglobin subunit beta; Hemoglobin subunit zeta;
Hemoglobin variants occur when there are mutations in specific genes that code for the protein chains, known as globins, which make up the hemoglobin molecule. This leads to amino acid substitutions in the hemoglobin molecule that could affect the structure, properties, and/or the stability of the hemoglobin molecule.
All values in Hematology – red blood cells (except hemoglobin in plasma) All values in Hematology – white blood cells; Platelet count (Plt) A few values are for inside red blood cells only: Vitamin B 9 (folic acid/folate) in red blood cells; Mean corpuscular hemoglobin concentration (MCHC)
Although the prevalence of anaemia (low levels of haemoglobin in the blood) has been found quite high among all population groups in Punjab, it was still higher among the SC population than other groups. For the women between the ages of 15 and 49 years, the prevalence of anaemia among SC women was 56.9%, compared to 53.5% for the state as a whole.
A hemoglobin test measures the amount of hemoglobin in your blood. If a hemoglobin tests shows that a person's levels are below normal, it means they have a low red blood cell count, which is known as anemia. If the test shows higher levels than normal, it means they have hemoglobinemia. [citation needed] The normal range for hemoglobin is: