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The enzyme involved in making 1-deoxy-d-xylulose 5-phosphate (DXP) is DXP synthase. [2] The mechanism follows a catalysis of decarboxylative condensation of pyruvate and d-glyceraldehyde 3-phosphate to produce DXP. [2] [3] In addition, the molecule is involved in making thiamine (vitamin B 1) and pyridoxol (vitamin B 6). [2]
In enzymology, a 1-deoxy-d-xylulose-5-phosphate synthase (EC 2.2.1.7) is an enzyme in the non-mevalonate pathway that catalyzes the chemical reaction pyruvate + d -glyceraldehyde 3-phosphate ⇌ {\displaystyle \rightleftharpoons } 1-deoxy- d -xylulose 5-phosphate + CO 2
DXP reductoisomerase (also known as: DXR, DOXP reductoisomerase, IspC, MEP synthase), is a key enzyme in the MEP pathway. It can be inhibited by the natural product fosmidomycin , which is under study as a starting point to develop a candidate antibacterial or antimalarial drug.
D-Xylulose 5-phosphate (D-xylulose-5-P) is an intermediate in the pentose phosphate pathway. It is a ketose sugar formed from ribulose-5-phosphate by ribulose-5-phosphate epimerase. In the non-oxidative branch of the pentose phosphate pathway, xylulose-5-phosphate acts as a donor of two-carbon ketone groups in transketolase reactions. [1]
DXP may refer to: 1-Deoxy-D-xylulose 5-phosphate, chemical compound; 1-deoxy-D-xylulose-5-phosphate synthase (also DXP-synthase), an enzyme; Deep eXecution Processor, a class of processor made by British multinational fabless semiconductor company Icera; Domino's DXP, custom third-generation Chevrolet Sparks commissioned by Domino's Pizza
In Arabidopsis thaliana 1-deoxy-D-xylulose 5-phosphate reductoisomerase is the first committed enzyme of the MEP pathway for isoprenoid precursor biosynthesis. The enzyme requires Mn 2+, Co 2+ or Mg 2+ for activity, with Mn 2+ being most effective.
Diethyl chlorophosphate is an organophosphorus compound with the formula (C 2 H 5 O) 2 P(O)Cl. As a reagent in organic synthesis, it is used to convert alcohols to the corresponding diethylphosphate esters. It is a colorless liquid with a fruity odor. It is a corrosive, and as a cholinesterase inhibitor, highly toxic through dermal absorption. [1]
[4] [5] Despite being named as a phosphite the compound exists overwhelmingly in its phosphonate form, (C 2 H 5 O) 2 P(O)H, a property it shares with its parent acid phosphorous acid. Nonetheless many of its reactions appear to proceed via the minor phosphorus(III) tautomer .