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  2. Juno Therapeutics - Wikipedia

    en.wikipedia.org/wiki/Juno_Therapeutics

    In May 2015, the company announced its intention to acquire Stage Cell Therapeutics for up to $223 million. [6] Later in the same month the company launched a collaboration, with Editas Medicine, to create CAR-T and high-affinity T cell receptor therapies to treat cancer, with the potential to generate up to $737 million-plus for Editas. [7]

  3. CAR T cell - Wikipedia

    en.wikipedia.org/wiki/CAR_T_cell

    A first generation CAR containing a CD4 extracellular domain and a CD3ζ intracellular domain was used in the first clinical trial of chimeric antigen receptor T cells by the biotechnology company Cell Genesys in the mid 1990s, allowing adoptively transferred T cells to target HIV infected cells, although it failed to show any clinical ...

  4. Prescient Therapeutics - Wikipedia

    en.wikipedia.org/wiki/Prescient_Therapeutics

    In pre-clinical trials Prescient demonstrated cells produced by CellPryme-M are less prone to exhaustion, enabling longer duration of cancer killing activity, and are capable of improved tumour trafficking and penetrance compared to the current generation of CAR-T cells. Resultantly, CellPryme-M CAR-T cells performed significantly better than ...

  5. Cellectis - Wikipedia

    en.wikipedia.org/wiki/Cellectis

    Cellectis has developed CAR T-cell treatments for blood cancer. [11] Most CAR-T therapies under development as of 2017 involved taking T-cells from the person with cancer and applying gene therapy to those cells to activate them to attack the person's cancer; an autologous cell therapy approach.

  6. List of largest biomedical companies by revenue - Wikipedia

    en.wikipedia.org/wiki/List_of_largest_biomedical...

    The change column indicates the company's relative position in this list compared to its relative position in the preceding year; i.e., an increase would be moving closer to rank 1 and vice versa. Green cells indicate years where revenue increased compared to the preceding year. Red cells indicate those years when there has been a decrease.

  7. Engineered CAR T cell delivery - Wikipedia

    en.wikipedia.org/wiki/Engineered_CAR_T_cell_delivery

    Engineered chimeric antigen receptor (CAR)-T cell delivery is the methodology by which clinicians introduce the cancer-targeting therapeutic system of the CAR-T cell to the human body. CAR-T cells, which utilizes genetic modification of human T-cells to contain antigen binding sequences in addition to the receptor systems CD4 or CD8 , are ...

  8. Cellular adoptive immunotherapy - Wikipedia

    en.wikipedia.org/wiki/Cellular_adoptive...

    CAR-T kill tumor cells specifically by targeting the tumor-associated antigens to keep the damage to healthy tissue at a minimum level. Additionally, these engineered T-cells can perform their function independent from HLA - major histocompatibility complex (MHC) presentation. Furthermore, CAR structure can be manipulated flexibly to target ...

  9. SCTbio - Wikipedia

    en.wikipedia.org/wiki/SCTbio

    It operates in Europe and North America. The company is recognized as good in the development of autologous cell-based products, cell banking, and all needle-to-needle GMP operations, including a validated apheresis collection sites network, product manufacturing, QC, GMP storage, QA/QP release, and worldwide drug products supply for clinical ...