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2,2,4,4-Tetramethyl-3-t-butyl-pentane-3-ol or tri-tert-butylcarbinol is an organic compound with formula C 13 H 28 O, ((H 3 C) 3 C) 3 COH, or t Bu 3 COH. [1] It is an alcohol that can be viewed as a structural analog of a tridecane isomer ( 2,2,4,4-tetramethyl-3- t -butylpentane ) where the central hydrogen has been replaced by a hydroxyl group ...
[2] [3] [4] The aldol reaction is paradigmatic in organic chemistry and one of the most common means of forming carbon–carbon bonds in organic chemistry . [ 5 ] [ 6 ] [ 7 ] It lends its name to the family of aldol reactions and similar techniques analyze a whole family of carbonyl α-substitution reactions , as well as the diketone ...
The water produced by the reaction as well as some acid will co-distill, giving a distillate mixture (2). The product is isolated from the mixture by the following work-up: [3] Synthesis of 4-methylcyclohexene with work-up step in red. A concentrated solution of sodium chloride in water, known as a brine solution, is added to the mixture and ...
Its sodium salt can be prepared from the chloride: [6] (C 6 H 5) 3 CCl + 2 Na → (C 6 H 5) 3 CNa + NaCl. The use of tritylsodium as a strong, non-nucleophilic base has been eclipsed by the popularization of butyllithium and related strong bases. The unmodified anion is red, and can be used as an indicator in acid–base titrations. Derived ...
[21] [22] Reductive amination can occur sequentially in one-pot reactions, which eliminates the need for intermediate purifications and reduces waste. [21] Some multistep synthetic pathways have been reduced to one step through one-pot reductive amination. [21] This makes it a highly appealing method to produce amines in green chemistry.
Some water-reactive substances are also pyrophoric, like organometallics and sulfuric acid. The use of acid-resistant gloves and face shield is recommended for safe handling; fume hoods are another effective control of such substances. [4] Water-reactive substances are classified as R2 under the UN classification system and as Hazard 4.3 by the ...
The alkylphosphonium salt is deprotonated with a strong base such as n-butyllithium: [Ph 3 P + CH 2 R]X − + C 4 H 9 Li → Ph 3 P=CHR + LiX + C 4 H 10. Besides n-butyllithium (n BuLi), other strong bases like sodium and potassium t-butoxide (t BuONa, t BuOK), lithium, sodium and potassium hexamethyldisilazide (LiHMDS, NaHMDS, KHDMS, where HDMS = N(SiMe 3) 2), or sodium hydride (NaH) are also ...
The reaction consumes one equivalent of metal alkoxide. Commonly, diethylsuccinate is a component of the reaction. The usual product is salt of the half-ester. The Stobbe condensation is named after its discoverer, Hans Stobbe, whose work involved the sodium ethoxide-induced condensation of acetone and diethyl succinate. [2]