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  2. Aldosterone synthase - Wikipedia

    en.wikipedia.org/wiki/Aldosterone_synthase

    Aldosterone synthase, also called steroid 18-hydroxylase, corticosterone 18-monooxygenase or P450C18, is a steroid hydroxylase cytochrome P450 enzyme involved in the biosynthesis of the mineralocorticoid aldosterone and other steroids. The enzyme catalyzes sequential hydroxylations of the steroid angular methyl group at C18 after initial 11β ...

  3. Steroidogenic enzyme - Wikipedia

    en.wikipedia.org/wiki/Steroidogenic_enzyme

    11β-Hydroxylase – corticosteroid synthesis; 17α-Hydroxylase – androgen and glucocorticoid synthesis; 18-Hydroxylase (aldosterone synthase) – mineralocorticoid synthesis; 21-Hydroxylase – corticosteroid synthesis; Cytochrome P450 (CYP1, 2, 3) – estrogen metabolism; Hydroxysteroid dehydrogenases (and ketosteroid reductases)

  4. Corticosteroid - Wikipedia

    en.wikipedia.org/wiki/Corticosteroid

    These enzymes are nearly identical (they share 11β-hydroxylation and 18-hydroxylation functions), but aldosterone synthase is also able to perform an 18-oxidation. Moreover, aldosterone synthase is found within the zona glomerulosa at the outer edge of the adrenal cortex; 11β-hydroxylase is found in the zona fasciculata and zona glomerulosa.

  5. Glucocorticoid remediable aldosteronism - Wikipedia

    en.wikipedia.org/wiki/Glucocorticoid_remediable...

    The genes encoding aldosterone synthase and 11β-hydroxylase are 95% identical and are close together on chromosome 8. In individuals with GRA, there is unequal crossing over so that the 5' regulatory region of the 11-hydroxylase gene is fused to the coding region of the aldosterone synthase. [citation needed]

  6. Corticosterone - Wikipedia

    en.wikipedia.org/wiki/Corticosterone

    Corticosterone, also known as 17-deoxycortisol and 11β,21-dihydroxyprogesterone, [1] is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands. In the very rare case of congenital adrenal hyperplasia due to 17α-hydroxylase deficiency cortisol production is blocked.

  7. Aldosterone - Wikipedia

    en.wikipedia.org/wiki/Aldosterone

    These enzymes are nearly identical (they share 11β-hydroxylation and 18-hydroxylation functions), but aldosterone synthase is also able to perform an 18-oxidation. Moreover, aldosterone synthase is found within the zona glomerulosa at the outer edge of the adrenal cortex; 11β-hydroxylase is found in the zona glomerulosa and zona fasciculata.

  8. 11β-Hydroxysteroid dehydrogenase - Wikipedia

    en.wikipedia.org/wiki/11β-Hydroxysteroid...

    (The other differences between the diagrams are not of consequence.) Cortisone. Cortisol, a glucocorticoid, binds the glucocorticoid receptor. However, because of its molecular similarity to aldosterone it also binds the mineralcorticoid receptor at higher concentrations. Both aldosterone and cortisol have a similar affinity for the ...

  9. 18-Hydroxycorticosterone - Wikipedia

    en.wikipedia.org/wiki/18-Hydroxycorticosterone

    Corticosteroid biosynthetic pathway in rat [citation needed] 18-Hydroxycorticosterone serves as an intermediate in the synthesis of aldosterone by the enzyme aldosterone synthase in the zona glomerulosa. [6] It is also an intermediate in the biosynthesis of corticosterone.