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A meta-analysis of such expression profiles was performed to derive novel conclusions and to validate the known findings. [148] Meta-analysis of whole genome sequencing studies provides an attractive solution to the problem of collecting large sample sizes for discovering rare variants associated with complex phenotypes.
The aim of the PRISMA statement is to help authors improve the reporting of systematic reviews and meta-analyses. [3] PRISMA has mainly focused on systematic reviews and meta-analysis of randomized trials, but it can also be used as a basis for reporting reviews of other types of research (e.g., diagnostic studies, observational studies).
Examples of such works are scientific reviews and meta-analyses. These and related practices face various challenges and are a subject of metascience. Various issues with included or available studies such as, for example, heterogeneity of methods used may lead to faulty conclusions of the meta-analysis. [115]
A subsequent meta-analysis published in 2011, based on the original data, found flaws in the 2010 analyses and suggested that the data indicated reboxetine was effective in severe depression (see Reboxetine § Efficacy). Examples of publication bias are given by Ben Goldacre [40] and Peter Wilmshurst. [41]
A systematic review is a scholarly synthesis of the evidence on a clearly presented topic using critical methods to identify, define and assess research on the topic. [1] A systematic review extracts and interprets data from published studies on the topic (in the scientific literature), then analyzes, describes, critically appraises and summarizes interpretations into a refined evidence-based ...
Rind et al. replied that Spiegel misrepresented their analysis, since they did not use Landis' study in the meta-analysis of childhood sexual abuse – symptom correlations, but only for examining the self-reported effects of CSA. They contend that the way they handled Landis' data maximized negative reports and minimized the possible deflating ...
Despite skepticism about extreme statements made in the paper, Ioannidis's broader argument and warnings have been accepted by a large number of researchers. [7] The growth of metascience and the recognition of a scientific replication crisis have bolstered the paper's credibility, and led to calls for methodological reforms in scientific research.
Pages in category "Meta-analysis" The following 27 pages are in this category, out of 27 total. This list may not reflect recent changes. ...