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In order to be considered pathological, the ICSD-II requires that in the sleep-related rhythmic movements should “markedly interfere with normal sleep, cause significant impairment in daytime function, or result in self-inflicted bodily injury that requires medical treatment (or would result in injury if preventive measures were not used)”.
However, in 1973, "wrinkly skin syndrome" received its name because of its characterized features of exceedingly wrinkled skin in the hands and feet in a number of related patients. In the same year, WSS was established as a new heritable disorder of connective tissue that appeared to be transmitted as an . [ 16 ]
Adverse effects of these agents have been reported and include the occurrence of restless leg syndrome triggered by the medication, as well as cortical arousals, which are a cause of disturbed sleep. [4] Patients must stay on these medications in order to experience relief, because there is no known cure for this disorder.
Peripheral neuropathy may be classified according to the number and distribution of nerves affected (mononeuropathy, mononeuritis multiplex, or polyneuropathy), the type of nerve fiber predominantly affected (motor, sensory, autonomic), or the process affecting the nerves; e.g., inflammation (), compression (compression neuropathy), chemotherapy (chemotherapy-induced peripheral neuropathy).
Sleep disruption may leave people with RLS sleepy during the day, with low energy, and irritable or depressed. [2] Additionally, many have limb twitching during sleep, a condition known as periodic limb movement disorder. [11] RLS is not the same as habitual foot-tapping or leg-rocking. [12]
Performance anxiety can also cause anorgasmia or delayed climax. Associated with a lack of satisfaction, this condition can make it difficult to achieve satisfcation, even with stimulation ...
There is support for treating any accompanying anxiety using cognitive behavioral therapy or antidepressants. [1] Quinine is effective, but not recommended because of the potential for serious side effects. [2] Calcium channel blockers may be effective, although the evidence for their use is weak. [2] There is little evidence supporting other ...
Werner syndrome patients exhibit growth retardation, short stature, premature graying of hair, alopecia (hair loss), wrinkling, prematurely aged faces with beaked noses, skin atrophy (wasting away) with scleroderma-like lesions, lipodystrophy (loss of fat tissues), abnormal fat deposition leading to thin legs and arms, and severe ulcerations around the Achilles tendon and malleoli (around ankles).
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