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The main source of polyphenols is dietary, since they are found in a wide array of phytochemical-bearing foods.For example, honey; most legumes; fruits such as apples, blackberries, blueberries, cantaloupe, pomegranate, cherries, cranberries, grapes, pears, plums, raspberries, aronia berries, and strawberries (berries in general have high polyphenol content [5]) and vegetables such as broccoli ...
Adverse effects of polyphenol intake range from mild (e.g., gastrointestinal tract symptoms) [2] to severe (e.g., hemolytic anemia or hepatotoxicity). [83] In 1988, hemolytic anemia following polyphenol consumption was documented, resulting in the withdrawal of a catechin -containing drug. [ 84 ]
Clinical studies investigating the relationship between flavonoid consumption and cancer prevention or development are conflicting for most types of cancer, probably because most human studies have weak designs, such as a small sample size. [1] [30] There is little evidence to indicate that dietary flavonoids affect human cancer risk in general ...
The Mayo Clinic diet, a program that adheres to this notion, was developed by medical professionals based on scientific research, so you can trust that this program is based on science, and not ...
On the contrary, research indicates that although polyphenols are antioxidants in vitro, antioxidant effects in vivo are probably negligible or absent. [3] [4] [5] By non-antioxidant mechanisms still undefined, polyphenols may affect mechanisms of cardiovascular disease or cancer. [6]
Phytochemicals are generally regarded as research compounds rather than essential nutrients because proof of their possible health effects has not been established yet. [4] [5] Phytochemicals under research can be classified into major categories, such as carotenoids [6] and polyphenols, which include phenolic acids, flavonoids, stilbenes or ...
In animals and humans, after ingestion, natural phenols become part of the xenobiotic metabolism. In subsequent phase II reactions, these activated metabolites are conjugated with charged species such as glutathione, sulfate, glycine or glucuronic acid. These reactions are catalysed by a large group of broad-specificity transferases.
Flax seeds and sesame seeds contain high levels of lignans. [1] [8] The principal lignan precursor found in flaxseeds is secoisolariciresinol diglucoside.[1] [8] Other foods containing lignans include cereals (rye, wheat, oat and barley), soybeans, tofu, cruciferous vegetables (such as broccoli and cabbage), and some fruits (particularly apricots and strawberries). [1]
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