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In the 1960s and 1970s, John Vane and others discovered the basic mechanism of aspirin's effects, [3]: 226–231 while clinical trials and other studies from the 1960s to the 1980s established aspirin's efficacy as an anti-clotting agent that reduces the risk of clotting diseases.
Aspirin is not recommended in the last part of pregnancy. [10] It is not generally recommended in children with infections because of the risk of Reye syndrome. [10] High doses may result in ringing in the ears. [10] A precursor to aspirin found in the bark of the willow tree (genus Salix) has been used for its health effects for at least 2,400 ...
It is certainly untrue that the inventors of aspirin were trying to find a substitute for willow bark; they were investigating the properties of a variety of acetylated organic compounds created in the laboratory, as a result of the discovery of acetanilide in the 1880s. [13]
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Heinrich Dreser, 1897. Heinrich Dreser (1 October 1860 – 21 December 1924) was a German chemist responsible for the aspirin and heroin projects at Bayer AG.He was also a key figure in creating the widely used modern drug codeine.
Felix Hoffmann (21 January 1868 – 8 February 1946) was a German chemist notable for re-synthesising diamorphine (independently from C.R. Alder Wright who synthesized it 23 years earlier), which was popularized under the Bayer trade name of "heroin".
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[3]: 7 Florida Gulf Coast orchestra becomes The Florida Orchestra. [4]: 208 1985 Severe drought results in watering restrictions. [3]: 7 A four-cent local option gas tax is passed by the Board of County Commissioners. Hurricane Elena threatens Florida. [3]: 7 1990 First segment of Pinellas Trail opens between Dunedin and Seminole.