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The latent TGF-beta binding proteins (LTBP) are a family of carrier proteins. [ 1 ] [ 2 ] LTBP is a family of secreted multidomain proteins that were originally identified by their association with the latent form of transforming growth factors .
Latent-transforming growth factor beta-binding protein 1 is a protein that in humans is encoded by the LTBP1 gene. [ 5 ] [ 6 ] [ 7 ] The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs).
Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes three [1] different mammalian isoforms (TGF-β 1 to 3, HGNC symbols TGFB1, TGFB2, TGFB3) and many other signaling proteins. TGFB proteins are produced by all white blood cell lineages.
All three TGFβ1, TGFβ2 and TGFβ3. are synthesized as precursor molecules containing a propeptide region in addition to the TGF-β homodimer. [10] After it is synthesized, the TGF-β homodimer interact with a Latency Associated Peptide (LAP)[a protein derived from the N-terminal region of the TGF beta gene product] forming a complex called Small Latent Complex (SLC).
Latent-transforming growth factor beta-binding protein 2 is a protein that in humans is encoded by the LTBP2 gene. [5] [6]The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure.
Transforming growth factor-beta (TGF-beta) [6] is a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types. TGF-beta-1 is a peptide of 112 amino acid residues derived by proteolytic cleavage from the C-terminal of a precursor protein.
16998 Ensembl ENSG00000168056 ENSMUSG00000024940 UniProt Q9NS15 Q61810 RefSeq (mRNA) NM_001130144 NM_001164266 NM_021070 NM_008520 RefSeq (protein) NP_001123616 NP_001157738 NP_066548 NP_032546 Location (UCSC) Chr 11: 65.54 – 65.56 Mb Chr 19: 5.79 – 5.81 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Latent-transforming growth factor beta-binding protein 3 is a protein that in ...
αvβ6-Integrin, the biological target of 68 Ga-Trivehexin, is a heterodimeric transmembrane cell adhesion receptor whose primary natural ligand is latency associated peptide (LAP) [2] in its complex with transforming growth factor beta 1 (TGF-β1). [3] Binding of αvβ6-integrin to LAP releases [4] and thus, activates [5] TGF-β1. In early ...