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A 2006 US government study of hospital emergency department (ED) visits found that sedative-hypnotics were the most frequently implicated pharmaceutical drug in visits, with benzodiazepines accounting for the majority of these. Clonazepam was the second most frequently implicated benzodiazepine in ED visits.
The evidence suggesting a link between benzodiazepines (and Z-Drugs) and pancreatic inflammation is very sparse and limited to a few observational studies from Taiwan. [159] [160] A criticism of confounding can be applied to these findings as with the other controversial associations above. Further well-designed research from other populations ...
Finally, note that the benzodiazepine core is a privileged scaffold, which has been used to derive drugs with diverse activity that is not limited to the GABA A modulatory action of the classical benzodiazepines, [60] such as devazepide and tifluadom, however these have not been included in the list below. 2,3-benzodiazepines such as tofisopam ...
Some packages of clonazepam were labeled with the incorrect dosage strength and National Drug Code (NDC), which is the FDA's identifier for drugs, according to Endo, Inc., the drug's manufacturer.
Clonazepam, in a class of medications called benzodiazepines, works by, "decreasing abnormal electrical activity in the brain," according to the U.S. National Library of Medicine.
Tablets of the drug clonazepam, the generic name for Klonopin, which is used to treat epilepsy, panic disorder and muscle spasms, have been recalled for incorrect labeling that could inadvertently ...
Cloniprazepam is a benzodiazepine derivative and a prodrug of clonazepam, 7-aminoclonazepam, and other metabolites. [ 1 ] [ 2 ] Some of the minor metabolites include 3-hydroxyclonazepam and 6-hydroxyclonazepam , 3-hydroxycloniprazepam and ketocloniprazepam with ketone group formed where 3-hydroxy group was.
The synthesis of clonazolam was first reported in 1971 and the drug was described as the most active compound in the series tested. [7] Depending on dose consumed, clonazolam may pose comparatively higher risk than other designer benzodiazepines due to its ability to produce strong sedation and amnesia at doses as small as 0.5 mg. [2] [8]