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NLRP3 is expressed predominantly in macrophages and as a component of the inflammasome, [7] [8]: 436 detects products of damaged cells such as extracellular ATP and crystalline uric acid. Activated NLRP3 in turn triggers an immune response. Mutations in the NLRP3 gene are associated with a number of organ specific autoimmune diseases.
140 11542 Ensembl ENSG00000282608 ENSMUSG00000000562 UniProt P0DMS8 Q61618 Q3U4C5 RefSeq (mRNA) NM_001302679 NM_000677 NM_001302678 NM_009631 RefSeq (protein) NP_000668 NP_001289607 NP_001289608 NP_033761 Location (UCSC) Chr 1: 111.5 – 111.5 Mb Chr 3: 105.78 – 105.82 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The adenosine A 3 receptor, also known as ADORA3, is an adenosine ...
7134 21924 Ensembl ENSG00000114854 ENSMUSG00000091898 UniProt P63316 P19123 RefSeq (mRNA) NM_003280 NM_009393 RefSeq (protein) NP_003271 NP_033419 Location (UCSC) Chr 3: 52.45 – 52.45 Mb Chr 14: 30.93 – 30.93 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Troponin C, also known as TN-C or TnC, is a protein that resides in the troponin complex on actin thin filaments of striated ...
Glucose Hexokinase ATP ADP Glucose 6-phosphate Glucose-6-phosphate isomerase Fructose 6-phosphate Phosphofructokinase-1 ATP ADP Fructose 1,6-bisphosphate Fructose-bisphosphate aldolase Dihydroxyacetone phosphate + + Glyceraldehyde 3-phosphate Triosephosphate isomerase 2 × Glyceraldehyde 3-phosphate 2 × Glyceraldehyde-3-phosphate dehydrogenase NAD + + P i NADH + H + NAD + + P i NADH + H + 2 ...
Class II catalyse the production of PI(3)P from PI and PI(3,4)P 2 from PI(4)P; however, little is known about their role in immune cells. PI(3,4)P 2 has, however, been shown to play a role in the invagination phase of clathrin-mediated endocytosis. [17] C2α and C2β are expressed through the body, but expression of C2γ is limited to hepatocytes.
This catabolic pathway consumes glucose and produces ATP, NADH and pyruvate. A key step for the regulation of glycolysis is an early reaction in the pathway catalysed by phosphofructokinase‑1 (PFK1). When ATP levels rise, ATP binds an allosteric site in PFK1 to decrease the rate of the enzyme reaction; glycolysis is inhibited and ATP ...
Blebbistatin is a relatively strong fluorophore.When dissolved in water, it absorbs at 420 nm and emits at 490 nm however in DMSO or when perfused through cardiac tissue, it absorbs around 430 nm and emits around 560 nm, [22] therefore at high concentrations its fluorescence interferes with GFP imaging or FRET experiments. [7]
Mitogen-activated protein kinase 14, also called p38-α, is an enzyme that in humans is encoded by the MAPK14 gene. [5]MAPK14 encodes p38α mitogen-activated protein kinase (MAPK) which is the prototypic member of the p38 MAPK family.