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Hürthle cells arise from the follicular epithelium. A Hürthle cell is larger than a follicular cell, and polygonal with distinct cell borders. [2] Key features of these oncocytic cells include a granular cytoplasm that stains eosinophilic (pink on H&E stain), which is commonly due to the oncocytes' high content of mitochondria, and a ...
Hurthle cell carcinoma, a variant of follicular thyroid carcinoma. Oncocytoma, a tumour composed of oncocytes, may be found as a less common salivary gland neoplasm also known as oxyphilic adenoma. Renal oncocytoma, a kidney tumour composed of oncocytes.
Follicular thyroid cancer accounts for 15% of thyroid cancer and occurs more commonly in women over 50 years of age. Thyroglobulin (Tg) can be used as a tumor marker for well-differentiated follicular thyroid cancer. Thyroid follicular cells are the thyroid cells responsible for the production and secretion of thyroid hormones.
Hyalinizing trabecular tumor (d–f) is composed of trabeculae of elongated or polygonal cells admixed with abundant amounts of hyaline material negative for amyloid and positive for type IV collagen (f); Ki-67 is characteristically expressed in the cell membrane but not in the nuclei of the tumor cells (e). Follicular adenoma with signet ring ...
Hürthle cell neoplasm is a rare tumor of the thyroid, typically seen in women between the ages of 70 and 80 years old. When benign, it is called a Hürthle cell adenoma, and when malignant it is called a Hürthle cell carcinoma. Hürthle cell adenoma is characterized by a mass of benign Hürthle cells (Askanazy cells). [1]
Follicular thyroid cancer (10 to 20% of cases [34]) – occasionally seen in people with Cowden syndrome. Some include Hürthle cell carcinoma as a variant and others list it as a separate type. [4] [36] Medullary thyroid cancer (5 [34] to 8% of cases) – cancer of the parafollicular cells, often part of multiple endocrine neoplasia type 2. [37]
Thyroid follicular adenoma ranges in diameter from 3 cm on an average, but sometimes is larger (up to 10 cm) or smaller. The typical thyroid adenoma is solitary, spherical and encapsulated lesion that is well demarcated from the surrounding parenchyma. The color ranges from gray-white to red-brown, depending upon the cellularity of the adenoma
Hurthle cell tumor; Follicular adenoma, oxyphilic cell (C73.9) M8290/3 Oxyphilic adenocarcinoma Oncocytic carcinoma; Oncocytic adenocarcinoma; Hurthlecell carcinoma (C73.9) Hurthle cell adenocarcinoma; Follicular carcinoma, oxyphilic cell (C73.9) M8300/0 Basophil adenoma (C75.1) Mucoid cell adenoma; M8300/3 Basophil carcinoma (C75.1) Basophil ...