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Clostridioides difficile toxin B (TcdB) is a cytotoxin produced by the bacteria Clostridioides difficile. It is one of two major kinds of toxins produced by C. difficile , the other being a related enterotoxin ( Toxin A ).
Clostridioides difficile toxin A (TcdA) is a toxin produced by the bacteria Clostridioides difficile, formerly known as Clostridium difficile. [1] It is similar to Clostridioides difficile Toxin B. The toxins are the main virulence factors produced by the gram positive, anaerobic, [2] Clostridioides difficile bacteria.
Pathogenic C. difficile strains produce multiple toxins. [21] The most well-characterized are enterotoxin (Clostridium difficile toxin A) and cytotoxin (Clostridium difficile toxin B), both of which may produce diarrhea and inflammation in infected people, although their relative contributions have been debated. [20]
A C. difficile infection is often suspected because of foul-smelling diarrhea, but this does not confirm if the patient has a CDI. To confirm a CDI, a cytotoxin assay detects the cell's toxin B (ToxB) cytotoxicity in the fecal eluate. The presence of C. difficile toxin is confirmed by the anti-toxin antibodies' neutralization of the cytotoxic ...
Reineke et al. (2007) present an integrated model for the uptake and inositol phosphate-induced activation of toxin B. [4] Clostridioides difficile infection, caused by the actions of the homologous toxins TcdA and TcdB on colonic epithelial cells is due to binding to target cells which triggers toxin internalization into acidified vesicles ...
Toxin A and toxin B are two toxins produced by Clostridioides difficile. Toxin A and toxin B are glycosyltransferases that cause the antibiotic-associated pseudomembranous colitis and severe diarrhea that characterize disease presentation of C. diff infections. [7]
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