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Other causes include vasculitis and in situ thrombosis related to hypercoagulable states. [53] Additional mechanisms of peripheral artery disease include arterial spasm and fibromuscular dysplasia. [19] The cause and pathophysiology of arterial spasm are not fully understood, but it is hypothesised that they can occur secondary to trauma. [54]
Smaller arteries carry blood supply from the popliteal artery to the calf and into the foot. [4] Blockages caused by plaque build-up or atherosclerosis in any of these arteries can reduce leg blood circulation, causing leg pain that may interfere with daily life. [4] Standard popliteal bypass surgery involves the bypass of the popliteal artery. [5]
Patients with PAES mainly present with intermittent feet and calf pain associated with exercises and relieved with rest. [3] PAES can be diagnosed with a combination of medical history, physical examination, and advanced imaging modalities such as duplex ultrasound , computer tomography , or magnetic resonance angiography .
The major cause of acute limb ischaemia is arterial embolism (80%), while arterial thrombosis is responsible for 20% of cases. In rare instances, arterial aneurysm of the popliteal artery has been found to create a blood clot or embolism resulting in ischaemia.
The arterial compliance - the amount of tension produced per stretch of arteries, decreases with age, and the stiffness of arteries increases with age. [3] The structural change in blood vessels causes the elderly to be more susceptible to hypertension, which leads to complications in arteries, the heart and even the brain. [citation needed]
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This testing uncovered calcified arteries and a collection of soft tissue near the femoral arteries and veins, which lead to a disruption in the right femoral artery. Extensive analysis of the individual's condition lead medical professionals to the conclusion that Mönckeberg's arteriosclerosis was suspected as the cause for their symptoms.
Rest pain is a continuous burning pain of the lower leg or feet. It begins, or is aggravated, after reclining or elevating the limb and is relieved by sitting or standing. It is more severe than intermittent claudication, which is also a pain in the legs from arterial insufficiency. [citation needed]
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