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The drugs of this class act as agonists for serotonin 5-HT 1B and 5-HT 1D receptors at blood vessels and nerve endings in the brain. The first clinically available triptan was sumatriptan, which has been marketed since 1991. Triptans have largely replaced ergotamines, an older class of medications used to relieve migraine and cluster headaches. [3]
The triptan drug class includes 1st generation sumatriptan (which has poor bioavailability), and second generation zolmitriptan. [2] Due to their safety, efficacy and selectivity, triptans are considered first line agents for abortion of migraines. [2] These medications are selective 5-HT 1B/1D receptor agonists with some activity at 5-HT 1F.
Pages in category "Triptans" The following 11 pages are in this category, out of 11 total. This list may not reflect recent changes. ...
Many triptans, an older class of migraine drugs, appear to be more effective at pain management than newer, more expensive medications. Image credit: Amor Burakova/Stocksy.
Triptans are a family of tryptamine-based drugs used as abortive medication in the treatment of migraines and cluster headaches. They are selective 5-hydroxytryptamine/serotonin 1B/1D (5-HT 1B/1D) agonists. [1] Migraine is a complex disease which affects about 15% of the population and can be highly disabling. [2]
Medications are more effective if used earlier in an attack. [4] The frequent use of medication may result in medication overuse headache (MOH), in which the headaches become more severe and more frequent. [6] This may occur with triptans, ergotamines, and analgesics, especially opioids or narcotic analgesics.
Following is a list of antipsychotics, sorted by class. Antipsychotics. Antipsychotics by class Generic name Brand names Chemical class ATC code
Like all triptans, almotriptan has a high and specific affinity for serotonin 5-HT 1B/1D receptors. Binding of the drug to the receptor leads to vasoconstriction of the cranial (brain) blood vessels and thus affects the redistribution of blood flow. Almotriptan significantly increases cerebral blood flow and reduces blood flow through ...
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