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Despite most dissociatives' main mechanism of action being tied to NMDA receptor antagonism, some of these substances, which are nonselective in action and affect the dopamine [2] and/or opioid [3] systems, may be capable of inducing more direct and repeatable euphoria or symptoms which are more akin to the effects of typical "hard drugs" or ...
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This is an accepted version of this page This is the latest accepted revision, reviewed on 21 January 2025. The following is a list of mental disorders as defined at any point by the Diagnostic and Statistical Manual of Mental Disorders (DSM) or the International Classification of Diseases (ICD). A mental disorder, also known as a mental illness, mental health condition, or psychiatric ...
العربية; Asturianu; Башҡортса; Беларуская; Беларуская (тарашкевіца) Български; Boarisch; Català; Чӑвашла
Methoxetamine (MXE) is a dissociative hallucinogen that has been sold as a designer drug. [5] [6] It differs from many dissociatives such as ketamine and phencyclidine (PCP) that were developed as pharmaceutical drugs for use as general anesthetics in that it was designed specifically to increase the antidepressant effects of ketamine.
Opiates are considered drugs with moderate to high abuse potential and are listed on various "Substance-Control Schedules" under the Uniform Controlled Substances Act of the United States of America. In 2014, between 13 and 20 million people used opiates recreationally (0.3% to 0.4% of the global population between the ages of 15 and 65).
Recreational drug use is the use of one or more psychoactive drugs to induce an altered state of consciousness, either for pleasure or for some other casual purpose or pastime. [1] When a psychoactive drug enters the user's body, it induces an intoxicating effect. [1]
Dissociative disorders are characterized by distinct brain differences in the activation of various brain regions including the inferior parietal lobe, prefrontal cortex, and limbic system. [16] Those with dissociative disorders have higher activity levels in the prefrontal lobe and a more inhibited limbic system on average than healthy ...