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The spiral (cochlear) ganglion is a group of neuron cell bodies in the modiolus, the conical central axis of the cochlea. These bipolar neurons innervate the hair cells of the organ of Corti . They project their axons to the ventral and dorsal cochlear nuclei as the cochlear nerve , a branch of the vestibulocochlear nerve (CN VIII).
The cochlear nerve travels away from the cochlea of the inner ear where it starts as the spiral ganglia. Processes from the organ of Corti conduct afferent transmission to the spiral ganglia. It is the inner hair cells of the organ of Corti that are responsible for activation of afferent receptors in response to pressure waves reaching the ...
The vestibular nerve is one of the two branches of the vestibulocochlear nerve (the cochlear nerve being the other). In humans the vestibular nerve transmits sensory information from vestibular hair cells located in the two otolith organs (the utricle and the saccule) and the three semicircular canals via the vestibular ganglion of Scarpa.
The cell bodies of the cochlear nerve lie within the cochlea and collectively form the spiral ganglion, named for the spiral shape it shares with the cochlea. These central axons exit the cochlea at its base and form a nerve trunk , which, in humans, is approximately one inch long.
Cross-section through the spiral organ of Corti at greater magnification, showing position of the hair cells on the basement membrane. The organ of Corti is located in the scala media of the cochlea of the inner ear between the vestibular duct and the tympanic duct and is composed of mechanosensory cells, known as hair cells. [2]
Acoustic trauma occurs when a continuous transient sounds transfers enough energy to a cochlea to result in necrosis of the outer hair cells (OHC), inner hair cells (IHC), and cause glutamate excitotoxicity of first-order afferent neurons of the spiral ganglion (cochlear synaptopathy). This can occur when an impact or impulse sound like an ...
The cochlea is a portion of the inner ear that looks like a snail shell (cochlea is Greek for snail). [5] The cochlea receives sound in the form of vibrations, which cause the stereocilia to move. The stereocilia then convert these vibrations into nerve impulses which are taken up to the brain to be interpreted.
The drug is understood to damage multiple regions of the cochlea, causing the death of outer hair cells, as well as damage to the spiral ganglion neurons and cells of the stria vascularis. [27] Long-term retention of cisplatin in the cochlea may contribute to the drug's cochleotoxic potential. [28]