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In biology, a connexon, also known as a connexin hemichannel, is an assembly of six proteins called connexins that form the pore for a gap junction between the cytoplasm of two adjacent cells.
Gap junctions use protein complexes known as connexons to connect one cell to another. The proteins are called connexins . Gap junction proteins include the more than 26 types of connexin, and at least 12 non-connexin components that make up the gap junction complex or nexus . [ 4 ]
Connexins are commonly named according to their molecular weights, e.g. Cx26 is the connexin protein of 26 kDa. A competing nomenclature is the gap junction protein system, where connexins are sorted by their α (GJA) and β (GJB) forms, with additional connexins grouped into the C, D and E groupings, followed by an identifying number, e.g. GJA1 corresponds to Cx43.
Gap junction alpha-1 protein (GJA1), also known as connexin 43 (Cx43), is a protein that in humans is encoded by the GJA1 gene on chromosome 6. [5] [6] [7] As a connexin, GJA1 is a component of gap junctions, which allow for gap junction intercellular communication (GJIC) between cells to regulate cell death, proliferation, and differentiation. [8]
A connectome (/ k ə ˈ n ɛ k t oʊ m /) is a comprehensive map of neural connections in the brain, and may be thought of as its "wiring diagram". [2] An organism's nervous system is made up of neurons which communicate through synapses. A connectome is constructed by tracing the neuron in a nervous system and mapping where neurons are ...
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NorthConnex is a tolled motorway tunnel linking M1 Pacific Motorway at Wahroonga to M2 Hills Motorway at West Pennant Hills.NorthConnex is integrated within the existing Sydney Orbital Network and the need for integration work at either end has been identified to enable the safe merge of traffic on and off the M1 and M2, optimising motorway performance.
The Gulf Intracoastal Waterway (GIWW) and Mississippi River System connect Gulf Coast ports, such as Mobile, New Orleans, Baton Rouge, Houston, and Corpus Christi, with major inland ports, including Memphis, Kansas City, St. Louis, Chicago, St. Paul, Cincinnati, and Pittsburgh.