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IV iron infusion is a method of delivering a mixed solution of iron and saline from a drip through a needle directly into the vein and bloodstream. [14] The procedure takes place in a medical clinic and may take several hours depending on the iron preparation that has been prescribed.
Iron deficiency, or sideropenia, is the state in which a body lacks enough iron to supply its needs. Iron is present in all cells in the human body and has several vital functions, such as carrying oxygen to the tissues from the lungs as a key component of the hemoglobin protein, acting as a transport medium for electrons within the cells in the form of cytochromes, and facilitating oxygen ...
Iron deficiency protects against infection by creating an unfavorable environment for bacterial growth. Nevertheless, while iron deficiency might lessen infections by certain pathogenic diseases, it also leads to a reduction in resistance to other strains of viral or bacterial infections, such as Salmonella typhimurium or Entamoeba histolytica ...
Anemia of chronic disease (ACD) [1] [2] or anemia of chronic inflammation [3] is a form of anemia seen in chronic infection, chronic immune activation, and malignancy.These conditions all produce elevation of interleukin-6, which stimulates hepcidin production and release from the liver.
Iron-deficiency anemia is anemia caused by a lack of iron. [3] Anemia is defined as a decrease in the number of red blood cells or the amount of hemoglobin in the blood. [3] When onset is slow, symptoms are often vague such as feeling tired, weak, short of breath, or having decreased ability to exercise. [1]
The iron sucrose molecule is a polymer with two main molecules; sucrose (chemical formula C 12 H 22 O 11) and an iron (III) hydroxide (Na 2 Fe 5 O 8 •3(H 2 O)). These two components are in solution together, but are not bound to one another. [2] Iron sucrose is a type II complex, with two oxygen atoms bonded to each iron atom. [3]
Iron deficiency can be managed through an iron-rich diet or supplementation. Severe iron deficiency anemia may require oral iron therapy, typically with 300 mg of ferrous sulfate containing 60 mg of elemental iron. For those who do not respond to oral treatment, intravenous iron infusion or iron chelation for iron overload may be necessary. [169]
Chelation therapy removes iron from the blood. [5] This involves delivering iron chelating agents such as deferoxamine, deferiprone or deferasirox. [5] If iron overload has caused damage to end-organs, this is generally irreversible and may require transplantation. [clarification needed]
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