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Sundowning, or sundown syndrome, [1] is a neurological phenomenon wherein people with delirium or some form of dementia experience increased confusion and restlessness beginning in the late afternoon and early evening. It is most commonly associated with Alzheimer's disease but is also found in those
A normal brain on the left and a late-stage Alzheimer's brain on the right. During the final stage, known as the late-stage or severe stage, there is complete dependence on caregivers. [19] [33] [41] Language is reduced to simple phrases or even single words, eventually leading to complete loss of speech.
The biochemistry of Alzheimer's disease, the most common cause of dementia, is not yet very well understood. Alzheimer's disease (AD) has been identified as a proteopathy : a protein misfolding disease due to the accumulation of abnormally folded amyloid beta (Aβ) protein in the brain . [ 1 ]
A new study distinguishes between two distinct phases of Alzheimer's disease: an early, 'stealth' one without symptoms, and a second phase that aggressively damages the brain.
A recent study set out to elucidate what happens in the brains of individuals who develop biological markers of Alzheimer's disease — but never experience symptoms.
Alzheimer's is now the sixth-leading cause of death in the United States. It has risen 140.9% from 2000 to 2021. Deaths from heart disease and stroke have actually decreased during that time.
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