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Aripiprazole, sold under the brand names Abilify and Aristada, among others, is an atypical antipsychotic. [8] It is primarily used in the treatment of schizophrenia , bipolar disorder , and irritability associated with autism spectrum disorder ; [ 8 ] other uses include as an add-on treatment in major depressive disorder and tic disorders . [ 8 ]
Antipsychotics are completely metabolized in the body and the metabolites are excreted in urine. [56] These drugs have relatively long half-lives. [56] Each drug has a different half-life, but the occupancy of the D2 receptor falls off within 24 hours with atypical antipsychotics, while lasting over 24 hours for the typical antipsychotics. [64]
Antacids and chelating agents combine chemically in the body. Enzyme-substrate binding is a way to alter the production or metabolism of key endogenous chemicals, for example aspirin irreversibly inhibits the enzyme prostaglandin synthetase (cyclooxygenase) thereby preventing inflammatory response.
Drug metabolism is the metabolic breakdown of drugs by living organisms, usually through specialized enzymatic systems. More generally, xenobiotic metabolism (from the Greek xenos "stranger" and biotic "related to living beings") is the set of metabolic pathways that modify the chemical structure of xenobiotics, which are compounds foreign to an organism's normal biochemistry, such as any drug ...
Polonium in the body has a biological half-life of about 30 to 50 days. Caesium in the body has a biological half-life of about one to four months. Mercury (as methylmercury) in the body has a half-life of about 65 days. Lead in the blood has a half life of 28–36 days. [29] [30] Lead in bone has a biological half-life of about ten years.
Water is the top expert-recommended choice to stay hydrated, while seltzer, green tea, black coffee and protein shakes can also help support hydration, metabolism and nutrient intake. As always ...
The approval of aripiprazole lauroxil from the Food and Drug Administration in 2015 was solely for the treatment of schizophrenia in adults. The ability to supplement aripiprazole lauroxil with oral supplements of aripiprazole allows for dosing flexibility, which is important for the treatment of schizophrenia, as symptoms and intensity of the disease vary greatly from patient to patient.
Meet the experts: Carla Prado, PhD, RD, is the Canada Research Chair in Integrative Nutrition, Body Composition, and Energy Metabolism at the University of Alberta.