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In a medicine that is administered periodically, the trough level should be measured just before the administration of the next dose in order to avoid overdosing. [3] A trough level is contrasted with a "peak level" (C max), which is the highest level of the medicine in the body, and the "average level", which is the mean level over time. It is ...
Peak-to-trough ratio in pharmacokinetics is the ratio of peak (C max) and trough (C min) levels of a drug over its dosing interval (τ) at steady state.. Peak-to-trough ratio (PTR), also known as peak-to-trough variation or peak-to-trough fluctuation, is a parameter in pharmacokinetics which is defined as the ratio of C max (peak) concentration and C min (trough) concentration over a dosing ...
C max is the maximum (or peak) serum concentration that a drug achieves in a specified compartment or test area of the body after the drug has been administered and before the administration of a second dose. [1] It is a standard measurement in pharmacokinetics.
Another use is in the therapeutic drug monitoring of drugs with a narrow therapeutic index. For example, gentamicin is an antibiotic that can be nephrotoxic (kidney damaging) and ototoxic (hearing damaging); measurement of gentamicin through concentrations in a patient's plasma and calculation of the AUC is used to guide the dosage of this drug ...
The peak expiratory flow (PEF), also called peak expiratory flow rate (PEFR) and peak flow measurement, [1] is a person's maximum speed of expiration, as measured with a peak flow meter, a small, hand-held device used to monitor a person's ability to breathe out air.
A trough is an elongated area of lower air pressure. Since pressure is closely linked to wind, there are often changes in wind direction across a trough. If a trough forms in the mid-latitudes, a temperature difference at some distance between the two sides of the trough usually exists and the trough might become a weather front at some
Calorimetry may be used to monitor the course of a reaction, since the instantaneous heat flux of the reaction, which is directly related to the enthalpy change for the reaction, is monitored. Reaction calorimetry may be classified as a differential technique since the primary data collected are proportional to rate vs. time.
Depending on context, wave height may be defined in different ways: For a sine wave, the wave height H is twice the amplitude (i.e., the peak-to-peak amplitude): [1] =.; For a periodic wave, it is simply the difference between the maximum and minimum of the surface elevation z = η(x – c p t): [1] = {()} {()}, with c p the phase speed (or propagation speed) of the wave.