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Enzalutamide, sold under the brand name Xtandi, is a nonsteroidal antiandrogen (NSAA) medication which is used in the treatment of prostate cancer. [2] [9] It is indicated for use in conjunction with castration in the treatment of metastatic castration-resistant prostate cancer (mCRPC), [2] nonmetastatic castration-resistant prostate cancer, [2] and metastatic castration-sensitive prostate ...
[3] [4] [2] N-Desmethylenzalutamide is formed from enzalutamide in the liver by the cytochrome P450 enzymes CYP2C8 and CYP3A4. [4] It has a longer terminal half-life than enzalutamide (7.8 days versus 5.8 days).
While six out of ten were willing to consider a trade-off between life expectancy and intact sexual function, given the present knowledge of treatment benefits for clinically localized prostate cancer, four out of ten stated that they would under all circumstances choose treatment irrespective of the risk for waning sexual function.
Extend health span by reducing the risk of disease at the end of life Be tested for safety and efficacy on hundreds, possibly thousands of people in clinical trials Influence all-cause mortality
At the turn of the 20th Century, one could expect to live until 47 in the U.S. Now, medical advancements, like vaccines and antibiotics, and public health initiatives have increased life ...
Here’s what we know about extending your health span—or as Susan Golden, author of Stage (Not Age), puts it, your “joy span”—which, by the way, is nothing to sneeze at since women do ...
Enzalutamide, along with the in-development apalutamide and darolutamide, are newer, second-generation NSAAs. [60] Similarly to bicalutamide and the other first-generation NSAAs , they possess the same core mechanism of action of selective AR antagonism but are thought to bind to the androgen receptor with higher affinity, prevent nuclear ...
By David Bautz, PhD NASDAQ:EPIX READ THE FULL EPIX RESEARCH REPORT Business Update Positive Preliminary Results from Combination Therapy of EPI-7386 and Enzalutamide On October 28, 2022, ESSA ...
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