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  2. 5-Hydroxytryptophan - Wikipedia

    en.wikipedia.org/wiki/5-Hydroxytryptophan

    5-HTP is produced from the amino acid tryptophan through the action of the enzyme tryptophan hydroxylase. Tryptophan hydroxylase is one of the biopterin-dependent aromatic amino acid hydroxylases. Production of 5-HTP is the rate-limiting step in 5-HT (serotonin) synthesis. 5-HTP is normally rapidly converted to 5-HT by amino acid decarboxylase. [1]

  3. 7 Supplement Combos You Should Never Take Together ... - AOL

    www.aol.com/7-supplement-combos-never-together...

    “Combining St. John’s Wort with serotonin-boosting supplements like 5-HTP or SAMe can elevate serotonin levels too much, potentially leading to symptoms like restlessness and confusion ...

  4. Tetrahydrobiopterin deficiency - Wikipedia

    en.wikipedia.org/wiki/Tetrahydrobiopterin_deficiency

    Tetrahydrobiopterin is a cofactor in the production of L-DOPA from tyrosine and 5-hydroxy-L-tryptophan from tryptophan, which must be supplemented as treatment in addition to the supplements for classical PKU. [citation needed] Other underlying causes of tetrahydrobiopterin deficiency are: [2] 6-Pyruvoyltetrahydropterin synthase (PTPS) deficiency

  5. Oxitriptan - Wikipedia

    en.wikipedia.org/wiki/Oxitriptan

    MDMA is an empathogenic-entactogenic and serotonergic psychotropic drug used primarily for recreational, though sometimes also therapeutic, purposes.Among users of MDMA, the serotonergic effects of the drug are often of particular interest and concern: After consuming MDMA, serotonin concentrations are greatly reduced in the brain. 5-HTP is necessary for serotonin production and its ...

  6. Tetrahydrobiopterin - Wikipedia

    en.wikipedia.org/wiki/Tetrahydrobiopterin

    Tetrahydrobiopterin (BH 4, THB), also known as sapropterin (), [5] [6] is a cofactor of the three aromatic amino acid hydroxylase enzymes, [7] used in the degradation of amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin (5-hydroxytryptamine, 5-HT), melatonin, dopamine, norepinephrine (noradrenaline), epinephrine (adrenaline), and is a cofactor for the ...

  7. α-Methyl-5-hydroxytryptophan - Wikipedia

    en.wikipedia.org/wiki/Α-methyl-5-hydroxytryptophan

    [1] [2] It is the α-methylated derivative of 5-hydroxytryptophan (5-HTP), while αMS is the α-methylated analogue of serotonin. [1] [2] Along with α-methyltryptophan (α-MTP), α-Me-5-HTP has been suggested for potential therapeutic use in the treatment of conditions thought by some authors to be related to serotonin deficiency, such as ...

  8. 5-HT receptor - Wikipedia

    en.wikipedia.org/wiki/5-HT_receptor

    5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. [ 1 ] [ 2 ] [ 3 ] They mediate both excitatory and inhibitory neurotransmission .

  9. Aromatic L-amino acid decarboxylase deficiency - Wikipedia

    en.wikipedia.org/wiki/Aromatic_L-amino_acid_de...

    Autonomic symptoms including difficulties controlling temperature and blood sugar, excessive sweating and nasal congestion; Some people may develop cerebral folate deficiency, because O-methylation of the excessive amounts of L-DOPA can deplete methyl donors such as S-adenosyl methionine and levomefolic acid.

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