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The causes of feline hyperesthesia syndrome are highly disputed, largely due to the unknown pathophysiology of the syndrome and the variation in responses to different treatment methods. [1] [3] [4] [8] There are three main theories on the cause of the syndrome, as outlined below:
Cat-scratch disease has a worldwide distribution, but it is a nonreportable disease in humans, so public health data on this disease are inadequate. [22] Geographical location, present season, and variables associated with cats (such as exposure and degree of flea infestation ) all play a factor in the prevalence of CSD within a population. [ 23 ]
Podoconiosis causes bilateral yet asymmetrical leg swelling with overlying firm nodules. Early on, symptoms may include itching, tingling, widening of the forefoot, and swelling which then progress to soft edema, skin fibrosis, papillomatosis, and nodule formation resembling moss, giving rise to the disease's alternate name of "mossy foot" in some regions of the world. [3]
Feline disease refers to infections or illnesses that affect cats. They may cause symptoms, sickness or the death of the animal. Some diseases are symptomatic in one cat but asymptomatic in others. Feline diseases are often opportunistic and tend to be more serious in cats that already have concurrent sicknesses.
Heart disease is the most common underlying cause of arterial thromboembolism. It leads to the formation of blood clots in the heart, which leave it with the bloodstream and obstruct larger blood vessels , in cats mainly the aorta at the outlet of the two external iliac arteries .
It is a diagnosis of exclusion which means other possible urinary diseases which could cause bladder inflammation (e.g. feline urinary tract infections or urolithiasis) are ruled out. [5] Research is still being pursued regarding the causes of cystitis in cats, though the following principal risk factors have been identified: [14]
Cryptosporidiosis is a parasitic disease that is transmitted through contaminated food or water from an infected person or animal. Cryptosporidiosis in cats is rare, but they can carry the protozoan without showing any signs of illness. Cryptosporidiosis can cause profuse, watery diarrhea with cramping, abdominal pain, and nausea in people.
Sensory neuropathies are inherited conditions in dogs and cause an inability to feel pain and a loss of proprioception. Self-mutilation is often seen. No treatment has been found, and the prognosis is poor in severe cases. Several breeds are affected: Boxer symptoms usually occur around two months of age as a slowly progressive disease. [3]