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Metformin does not cause kidney damage by itself, however there is a risk of serious side effects if metformin is used when you have impaired renal function, Dr. Gupta notes.
Uremic pruritus is caused by chronic kidney failure and is the most common internal systemic cause of itching. [2]: 52–3 Nalfurafine, an orally administered, centrally acting κ-opioid receptor agonist, is approved to treat the condition in Japan. [3]
Another class of medications known to occasionally cause itching is known as serotonin reuptake inhibitors. [3] Itching is one of the most frequent adverse effects of opioid therapy. [4] A common artificial colloid used in clinical fluid management is hydroxyethyl starch (HES).
An itch can be caused by various reasons. The cause of senile pruritus is not clearly known, this type of itch in elderly patients may be a result of other reasons, like: [7] allergies; drug-induced pruritus; diseases mentioned under the Classification section of this article; underlying conditions, like kidney failure or gallbladder diseases ...
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The medication most commonly may cause stomach upset and symptoms such as diarrhea but in general is well tolerated and has a relatively low chance of causing hypoglycemia. [35] One rare (about 1% chance) but serious side affect of metformin is that it can cause lactic acidosis, usually in patients with poor kidney function. [35]
Symptoms of lactic acidosis include nausea, vomiting, and weakness. ... Taking metformin may cause unpleasant side effects like diarrhea, nausea, and an upset stomach. Taking it with food can ...
Failure of kidneys to remove excess fluid may cause: Swelling of the hands, legs, ankles, feet, or face; Shortness of breath due to extra fluid on the lungs (may also be caused by anemia) Polycystic kidney disease, which causes large, fluid-filled cysts on the kidneys and sometimes the liver, can cause: Pain in the back or side
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