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Loperamide, sold under the brand name Imodium, among others, [1] is a medication of the opioid receptor agonist class used to decrease the frequency of diarrhea. [5] [4] It is often used for this purpose in irritable bowel syndrome, inflammatory bowel disease, short bowel syndrome, [4] Crohn's disease, and ulcerative colitis. [5]
By binding to μ-opioid receptors, loperamide inhibits acetylcholine release and decreases excitation of neurons in the myenteric plexus, which leads to a decrease in peristalsis. [4] Decreasing intestinal motility prolongs the transit time of food content through the digestive tract, which allows for more fluid absorption; thereby alleviating ...
These peripherally selective opioids can be used as antidiarrheals, for instance loperamide (Imodium). [ 2 ] Mechanisms of peripheral selectivity include physicochemical hydrophilicity and large molecular size, which prevent drug permeation through the lipid bilayer cell membranes of the blood–brain barrier, and efflux out of the brain by ...
The FDA said it was working to determine whether the demand or projected demand for semaglutide within the U.S. exceeds the available supply, and that while compounded drugs serve an important ...
Nearly half of all 3,100 counties in America have no doctors certified to prescribe buprenorphine by the Substance Abuse and Mental Health Services Administration and the Drug Enforcement Administration, according to a Huffington Post analysis. Hundreds of counties have very few certified doctors.
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It does not address the underlying cause (for example, infection or malabsorption), but it does decrease motility. Examples include diphenoxylate , loperamide , and eluxadoline . See also
If something is wrong with your mobile web browser, it can cause AOL websites to stop working. Get back to what you're doing by fixing the source of the problem. Try each step in order, then check to see if the issue is resolved before moving on. 1. Check if your device is connected to a network. 2. Update your browser to the latest version. 3.