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Spironolactone is sometimes able to significantly lower testosterone levels at high dosages in spite of not acting as an antigonadotropin, and this is thought to be due to direct enzymatic inhibition of 17α-hydroxylase and 17,20-lyase, enzymes necessary for the biosynthesis of testosterone.
Although useful as an antiandrogen in women, who have low testosterone levels compared to men, [193] [194] spironolactone is described as having relatively weak antiandrogenic activity. [195] [191] [196] [197] Spironolactone is a weak steroidogenesis inhibitor.
The research suggested that eating trans fats may lower testosterone levels in the body, while too many omega-6 fatty acids appear to reduce the size and function of men's reproductive organs.
Spironolactone stops androgen from binding to receptors, which reduces testosterone and DHT levels and decreases hair loss. Women who are pregnant or trying to get pregnant shouldn’t take ...
An obesity-causing diet made up of high sugar and highly processed foods has also been linked to lower testosterone levels. So take all of this low-T talk with a grain of salt.
Due to its progestogenic (and by extension antigonadotropic) activity, CPA is able to suppress circulating testosterone levels by 70 to 80% in men at high dosages. [25] [94] In contrast, NSAAs increase testosterone levels by up to 2-fold via blockade of the AR, a difference that is due to their lack of concomitant antigonadotropic action. [95]
In fact, type 2 diabetes doubles the risk of low testosterone levels. Hypothyroidism . Also known as an underactive thyroid, hypothyroidism happens when your thyroid gland doesn't produce enough ...
Testosterone levels with 100 to 300 mg/day oral cyproterone acetate and low-dose oral estrogen in men. [11] The estrogen used was 0.1 mg/day diethylstilbestrol (DES), [11] which has been described as an "extremely low" dosage. [12] Levels of testosterone were decreased by about 95% with the combination and by about 61% with cyproterone acetate ...