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The cortico-basal ganglia-thalamo-cortical loop (CBGTC loop) is a system of neural circuits in the brain. The loop involves connections between the cortex , the basal ganglia , the thalamus , and back to the cortex.
Thalamo-cortico-thalamic circuits consist of looped neural pathways that connect the thalamus to the cerebral cortex, and connect the cerebral cortex back to the thalamus. Some researchers propose that such circuits allow the brain to obtain data on its own activity.
The cortico-basal ganglia-thalamo-cortical loop has been traditionally associated with reward-learning, and though has also been noted by some researchers to have a modulatory effect on thalamocortical network functioning, this is due to inherent activation of the premotor areas connecting the VA nucleus with the cortex. [22]
A major output from the cortex, with axons from most of the cortical regions connecting to the striatum, is called the corticostriatal connection, part of the cortico-basal ganglia-thalamo-cortical loop, or basal ganglia loop in short. [1] In the primate most of these axons are thin and unbranched.
The striatum (pl.: striata) or corpus striatum [5] is a cluster of interconnected nuclei that make up the largest structure of the subcortical basal ganglia. [6] The striatum is a critical component of the motor and reward systems; receives glutamatergic and dopaminergic inputs from different sources; and serves as the primary input to the rest of the basal ganglia.
Cortico-basal ganglia-thalamo-cortical loop [ edit ] The dopaminergic pathways that project from the substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) into the striatum (i.e., the nigrostriatal and mesolimbic pathways, respectively) form one component of a sequence of pathways known as the cortico-basal ganglia-thalamo ...
Cortico-striato-thalamocortical circuit, also known as cortico-basal ganglia-thalamo-cortical loop, a type of neural circuit in the brain Combined Security Transition Command – Afghanistan Topics referred to by the same term
The left side of Fig.1 shows a region of the prefrontal cortex receiving multiple inputs from other regions, as cortico-cortical activity. The input from B is the strongest of these. The right side of Fig. 1 shows the input signals also being fed to the basal ganglia circuitry.