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Apixaban is a highly selective, orally bioavailable, and reversible direct inhibitor of free and clot-bound factor Xa. Factor Xa catalyzes the conversion of prothrombin to thrombin, the final enzyme in the coagulation cascade that is responsible for fibrin clot formation. [ 27 ]
The p-methoxy group of apixaban connects to S1 pocket of FXa but does not appear to have any interaction with any residues in this region of FXa. The pyrazole N-2 nitrogen atom of apixaban interacts with Gln-192 and the carbonyl oxygen interacts with Gly-216. The phenyl lactam group of apixaban is positioned between Tyr-99 and Phe-174 and due ...
Side effects may include bleeding, most commonly from the nose, gastrointestinal tract (GI) or genitourinary system. [2] Compared to the risk of bleeding with warfarin use, direct factor Xa inhibitors have a higher risk of GI bleeding, but lower risk of bleeding in the brain. [2]
The game's theme song is "dis-dystopia", an image song performed by Ayane Sakura and Inori Minase as the characters Arche and Chica, respectively. [ 10 ] Farmagia was released worldwide on November 1, 2024, published by Marvelous for the PlayStation 5 , Nintendo Switch , and Steam , [ 8 ] with Marvelous USA handling the game's release in North ...
Free play, also known as unstructured play, represents the spontaneous, self-directed activity of young children, undertaken independently of adult or older peer guidance. Unlike structured play, characterized by predetermined rules, objectives , and often adult intervention, free play is intrinsically motivated and lacks specific goals or ...
Free to play with items and privileges that can be purchased from an item shop MMORPG in J. R. R. Tolkien's fantasy world Middle-earth, based on The Lord of the Rings. 3D Active Transformice: Atelier 801: 2010: Windows, OS X, Linux: MMO, Platform: Free play with in-game currency and items that can be purchased from a shop or earned through gameplay
An antiplatelet drug (antiaggregant), also known as a platelet agglutination inhibitor or platelet aggregation inhibitor, is a member of a class of pharmaceuticals that decrease platelet aggregation [1] and inhibit thrombus formation.
Series are listed in order of how many character articles they have, with series that have the same number being sorted in alphabetical order. Class and importance ratings (task force specific) are also displayed. If a series has a lot of characters, or clear-cut differences (ex. characters vs. species), it might be broken into further ...