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Apixaban is a highly selective, orally bioavailable, and reversible direct inhibitor of free and clot-bound factor Xa. Factor Xa catalyzes the conversion of prothrombin to thrombin, the final enzyme in the coagulation cascade that is responsible for fibrin clot formation. [ 27 ]
The p-methoxy group of apixaban connects to S1 pocket of FXa but does not appear to have any interaction with any residues in this region of FXa. The pyrazole N-2 nitrogen atom of apixaban interacts with Gln-192 and the carbonyl oxygen interacts with Gly-216. The phenyl lactam group of apixaban is positioned between Tyr-99 and Phe-174 and due ...
Side effects may include bleeding, most commonly from the nose, gastrointestinal tract (GI) or genitourinary system. [2] Compared to the risk of bleeding with warfarin use, direct factor Xa inhibitors have a higher risk of GI bleeding, but lower risk of bleeding in the brain. [2]
Free Fire grossed $1.4 million in the United States and Canada, and $1.2 million in other territories, for a total of $2.6 million. [3] In the United States and Canada, Free Fire opened alongside The Promise, Born in China, Unforgettable and Phoenix Forgotten, and was projected to gross around $3 million from 1,070 cinemas in its opening ...
Must be a defining trait – Characters with access to vast powers (such as magical spells, advanced technology and genetic engineering) who are theoretically capable of this superhuman feature or ability – but who have neither made regular use nor provided a notable example of this extraordinary or supernatural feat – are not listed here.
Free Fire Max is an enhanced version of Free Fire that was released in 2021. [ 71 ] [ 72 ] It features improved High-Definition graphics , sound effects , and a 360-degree rotatable lobby. Players can use the same account to play both Free Fire Max and Free Fire , and in-game purchases, costumes, and items are synced between the two games. [ 73 ]
Free Fire may refer to: Free Fire, a 2016 British action comedy film; Free Fire, a 2017 multiplayer online battle royale game; Free Fire, a ...
Pages in category "Video game characters with fire or heat abilities" The following 44 pages are in this category, out of 44 total. This list may not reflect recent changes .