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Depending on the extent of injury, the cellular response may be adaptive and where possible, homeostasis is restored. [1] Cell death occurs when the severity of the injury exceeds the cell's ability to repair itself. [2] Cell death is relative to both the length of exposure to a harmful stimulus and the severity of the damage caused. [1]
The Injury Severity Score (ISS) is an established medical score to assess trauma severity. [1] [2] It correlates with mortality, morbidity and hospitalization time after trauma. It is used to define the term major trauma. A major trauma (or polytrauma) is defined as the Injury Severity Score being greater than 15. [2]
Depending on the extent of injury, the cellular response may be adaptive and where possible, homeostasis is restored. [25] Cell death occurs when the severity of the injury exceeds the cell's ability to repair itself. [26] Cell death is relative to both the length of exposure to a harmful stimulus and the severity of the damage caused. [25]
Major trauma is a severe traumatic injury that has the potential to cause disability or death. Serious traumatic injury most often occurs as a result of traffic collisions. [11] Traumatic injury is the leading cause of death in people under the age of 45. [12] Blunt trauma injuries are caused by the forceful impact of an external object.
A wound is any disruption of or damage to living tissue, such as skin, mucous membranes, or organs. [1] [2] Wounds can either be the sudden result of direct trauma (mechanical, thermal, chemical), or can develop slowly over time due to underlying disease processes such as diabetes mellitus, venous/arterial insufficiency, or immunologic disease. [3]
The Abbreviated Injury Scale (AIS) is an anatomical-based coding system created by the Association for the Advancement of Automotive Medicine to classify and describe the severity of injuries. [1] [2] [3] It represents the threat to life associated with the injury rather than the comprehensive assessment of the severity of the injury. [4]
Necrosis (from Ancient Greek νέκρωσις (nékrōsis) 'death') is a form of cell injury which results in the premature death of cells in living tissue by autolysis. [1] The term "necrosis" came about in the mid-19th century and is commonly attributed to German pathologist Rudolf Virchow , who is often regarded as one of the founders of ...
A NACA score (or National Advisory Committee for Aeronautics score) is a scoring system of the severity in cases of medical emergencies such as injuries, diseases or poisonings. It was developed from the National Advisory Committee for Aeronautics for accidents in aviation. [1] [2]