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An aldol condensation is a condensation reaction in organic chemistry in which two carbonyl moieties (of aldehydes or ketones) react to form a β-hydroxyaldehyde or β-hydroxyketone (an aldol reaction), and this is then followed by dehydration to give a conjugated enone. The overall reaction equation is as follows (where the Rs can be H)
(Benzylideneacetone)iron tricarbonyl is an organoiron compound with an η 2 ketone ligand. Some η 2-aldehyde complexes insert alkenes to give five-membered metallacycles. [5] η 1-Complexes of alpha-beta unsaturated carbonyls exhibit enhanced reactivity toward dienes. This interaction is the basis of Lewis-acid catalyzed Diels-Alder reactions.
The Seyferth–Gilbert homologation is a chemical reaction of an aryl ketone 1 (or aldehyde) with dimethyl (diazomethyl)phosphonate 2 and potassium tert-butoxide to give substituted alkynes 3. [1] [2] Dimethyl (diazomethyl)phosphonate 2 is often called the Seyferth–Gilbert reagent. [3] The Seyferth–Gilbert homologation
The Buchner–Curtius–Schlotterbeck reaction is the reaction of aldehydes or ketones with aliphatic diazoalkanes to form homologated ketones. [1] It was first described by Eduard Buchner and Theodor Curtius in 1885 [2] and later by Fritz Schlotterbeck in 1907. [3]
The Dakin oxidation (or Dakin reaction) is an organic redox reaction in which an ortho- or para-hydroxylated phenyl aldehyde (2-hydroxybenzaldehyde or 4-hydroxybenzaldehyde) or ketone reacts with hydrogen peroxide (H 2 O 2) in base to form a benzenediol and a carboxylate. Overall, the carbonyl group is oxidised, whereas the H 2 O 2 is reduced.
The reaction was discovered by Teruaki Mukaiyama in 1973. [2] His choice of reactants allows for a crossed aldol reaction between an aldehyde and a ketone (>C=O), or a different aldehyde without self-condensation of the aldehyde. For this reason the reaction is used extensively in organic synthesis.
In organic chemistry, aldol reactions are acid- or base-catalyzed reactions of aldehydes or ketones. Aldol addition or aldolization refers to the addition of an enolate or enolation as a nucleophile to a carbonyl moiety as an electrophile. This produces a β-hydroxyaldehyde or β-hydroxyketone.
Dimethyl sulfide (Me 2 S) is treated with N-chlorosuccinimide (NCS), resulting in formation of an "active DMSO" species that is used for the activation of the alcohol. . Addition of triethylamine to the activated alcohol leads to its oxidation to aldehyde or ketone and generation of dimethyl