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This is a complete list of clinically approved prescription antidepressants throughout the world, as well as clinically approved prescription drugs used to augment antidepressants or mood stabilizers, by pharmacological and/or structural classification. Chemical/generic names are listed first, with brand names in parentheses.
The earliest and most widely known scientific theory of antidepressant action is the monoamine hypothesis, which can be traced back to the 1950s and 1960s. [ 200 ] [ 201 ] This theory states that depression is due to an imbalance, most often a deficiency, of the monoamine neurotransmitters , namely serotonin , norepinephrine , and/or dopamine .
In the late 1960s and early 1970s, Dexamyl spansules—a clear and green capsule containing green and white "beads"—became popular as a street-drug upper nicknamed "Christmas trees", a reference to its appearance. [6] In his autobiography My Life of Absurdity, author Chester Himes writes of his use of Dexamyl in the mid-1950s. He also writes ...
SSRI antidepressants all have the same mechanism of action and are at least 10-fold more selective for 5-HT re-uptake inhibition than for NE re-uptake inhibition. However, despite the sharing of the same mechanism of action, SSRIs differ in their potency and selectivity in inhibiting 5-HT re-uptake and many of them have important effects on ...
α-Methyltryptamine (αMT, AMT) is a psychedelic, stimulant, and entactogen drug of the tryptamine family. [5] [6] It was originally developed as an antidepressant at Upjohn in the 1960s, and was used briefly as an antidepressant in the Soviet Union under the brand name Indopan or Indopane before being discontinued.
During the 1960s the Rockland Research Institute grew to more than 300 staff. Kline's reputation drew biomedical researchers from around the world . Many laboratory techniques were developed to determine the therapeutic doses of frequently used medications, doses which are safe yet effective, at the Rockland Research Institute.
By the early 1960s, former members and others began branching out across the country forming their own versions of the Synanon model. These eventually were dubbed “therapeutic communities.” “It does sound harsh but you have to remember we were a community of drug addicts, recovering drug addicts, and these kind of punishments became rites ...
The main parameters to consider in choosing an antidepressant are side effects and safety. Most SSRIs are available generically and are relatively inexpensive. Older antidepressants such as TCAs and MAOIs usually require more visits and monitoring, which may offset the low expense of the drugs.