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In mature adults, glycine is a inhibitory neurotransmitter found in the spinal cord and regions of the brain. [15] As it binds to a glycine receptor, a conformational change is induced, and the channel created by the receptor opens. [17] As the channel opens, chloride ions are able to flow into the cell which results in hyperpolarization.
Glycine encephalopathy is a rare autosomal recessive disorder of glycine metabolism. After phenylketonuria, glycine encephalopathy is the second most common disorder of amino acid metabolism. The disease is caused by defects in the glycine cleavage system, an enzyme responsible for glycine catabolism. There are several forms of the disease ...
English: Glycine and serine catabolism in and out of the mitochondria. Inside the mitochondria, the glycine cleavage systems links to the serine hydroxymethyltransferase in a reversible process allowing for flux control in the cell.
The study collects data on the behavior and brain development of over 11,500 children beginning at age 9-10 and continuing through young adulthood. [2] The study collected data from youth in seven primary domains: physical health, mental health, brain imaging, biospecimens, neurocognition, substance use, and culture and environment.
Cyclic glycine-proline (cGP) is a small neuroactive peptide that belongs to a group of bioactive 2,5-diketopiperazines (2,5-DKPs) and is also known as cyclo-glycine-proline. cGP is a neutral, stable naturally occurring compound and is endogenous to the human body; found in human plasma, breast milk and cerebrospinal fluid.
Excitotoxicity may be involved in cancers, spinal cord injury, stroke, traumatic brain injury, hearing loss (through noise overexposure or ototoxicity), and in neurodegenerative diseases of the central nervous system such as multiple sclerosis, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), Parkinson's disease, alcoholism, alcohol ...
Her studies have explored neural mechanisms underlying decision-making and risk-taking, [16] [17] the influences of stress and other experiences on behavior and brain functioning, [18] [19] and neurobiological factors associated with cigarette smoking in adolescence. [20] Other influential work has focused on how sleep affects the developing ...
Download as PDF; Printable version; In other projects ... move to sidebar hide. A glycine receptor antagonist is a drug which acts as an antagonist of the glycine ...