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As a result of cholinergic crisis, the muscles stop responding to the high synaptic levels of acetylcholine, leading to flaccid paralysis, respiratory failure, and other signs and symptoms reminiscent of organophosphate poisoning. Other symptoms include increased sweating, salivation, bronchial secretions along with miosis (constricted pupils).
For people affected by cholinergic syndrome, atropine sulfate combined with an oxime is used to combat the effects of the acute OP poisoning. Diazepam is sometimes also administered if convulsions or muscle fasciculations begin. [16] The intermediate syndrome (IMS) appears in the interval between the end of the cholinergic crisis and the onset ...
Atropine resolves OP-induced cholinergic toxicity at muscarinic receptors in addition to aiding in central nervous system signs like bradycardia, respiratory depression, and bronchoconstriction. [ 7 ]
Cholinergic agents are compounds which mimic the action of acetylcholine and/or butyrylcholine. [1] In general, the word " choline " describes the various quaternary ammonium salts containing the N , N , N -trimethylethanolammonium cation .
Influenza is surging in the U.S., with doctor visits for flu symptoms at a 15-year high. Why is this flu season so bad? Doctors discuss flu trends and prevention.
Individuals symptoms vary in severity and type. Severe, subacute gastrointestinal dysmotility and orthostatic hypotension are the most common symptoms in two-thirds of patients. Symptoms can be severe in some cases and gradually worsen in others. [1] Sympathetic failure manifests itself as orthostatic hypotension and anhidrosis.
We’ve all had our moments of existential dread. Whether it’s feeling stuck on the hamster wheel of life or left behind as friends reach relationship and career milestones that for you seem ...
Here are the signs and ways to work through it. An existential crisis is about questioning your identity and purpose in life. It's not always a bad thing. Here are the signs and ways to work ...