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In contrast, acitretin's half-life is approximately 2 days. However, because acitretin can be reverse metabolised into etretinate which has an extremely long half-life, women must avoid becoming pregnant for at least three years [10] after discontinuing acitretin. Therefore, acitretin is generally not recommended for women of child-bearing age ...
Etretinate has been replaced by acitretin, the free acid (without the ethyl ester). While acitretin is less lipophilic and has a half-life of only 50 hours, it is partly metabolized to etretinate in the body, [ 2 ] so that it is still a long-acting teratogen and pregnancy is prohibited for two years after therapy.
Teratology is the study of abnormalities of physiological development in organisms during their life span. It is a sub-discipline in medical genetics which focuses on the classification of congenital abnormalities in dysmorphology caused by teratogens and also in pharmacology and toxicology.
Intermittent fasting is also not recommended for individuals with diabetes, anyone with a history of disordered eating, as well as women who are pregnant, trying to get pregnant, or breastfeeding ...
The new study found that women who had higher levels of fluoride during pregnancy reported later that their kids were more likely to have temper tantrums, complain of vague headaches and ...
A California man is in custody after allegedly running over a 16-year-old pregnant girl after she reportedly confronted him about his relationship with her underage sister.
A study of 71 female patients who received isotretinoin treatment from 2010 to 2020 at Children's National Hospital found that iPledge requirements unjustifiably increased the cost of treatment for patients with the potential to become pregnant, especially when windows were missed requiring additional follow up medical appointments and repeated ...
[33] [34] The use of acitretin, alitretinoin and isotretinoin should be prohibited in women of childbearing age unless they take measures to prevent pregnancy. [35] The use of topical retinoids should also be excluded during pregnancy and in women planning pregnancy. [citation needed]
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