Search results
Results from the WOW.Com Content Network
Chloramphenicol is a broad-spectrum antibiotic that typically stops bacterial growth by stopping the production of proteins. [5] Chloramphenicol was discovered after being isolated from Streptomyces venezuelae in 1947. [8] Its chemical structure was identified and it was first synthesized in 1949.
Examples of amphenicols include chloramphenicol, thiamphenicol, azidamfenicol, and florfenicol. The first-in-class compound was chloramphenicol, introduced in 1949. Chloramphenicol was initially discovered as a natural product and isolated from the soil bacteria Streptomyces venezuelae; [2] however, all amphenicols are now made by chemical ...
Mildred Catherine Rebstock (November 29, 1919 – February 17, 2011) was an American pharmaceutical chemist.She and her team were the first to fully synthesize chloromycetin, also known as chloramphenicol.
Streptomyces venezuelae [1] is a species of soil-dwelling [2] Gram-positive bacterium of the genus Streptomyces. [3] S. venezuelae is filamentous.In its spore-bearing stage, hyphae perfuse both above ground as aerial hyphae and in the soil substrate. [3]
1949 – chloramphenicol, the first amphenicol [2] 1949 – neomycin; 1950 – oxytetracycline; 1950 – penicillin G procaine; 1952 – erythromycin, the first macrolide [2] 1954 – benzathine penicillin; 1955 – spiramycin; 1955 – tetracycline; 1955 – thiamphenicol; 1955 – vancomycin, the first glycopeptide; 1956 ...
Streptomycetes produce over two-thirds of the clinically useful antibiotics of natural origin (e.g., neomycin, streptomycin, cypemycin, grisemycin, bottromycins and chloramphenicol). [9] [10] The antibiotic streptomycin takes its name directly from Streptomyces.
The history of the tetracyclines involves the collective contributions of thousands of dedicated researchers, scientists, clinicians, and business executives. Tetracyclines were discovered in the 1940s, first reported in scientific literature in 1948, and exhibited activity against a wide range of microorganisms.
Perhaps Smadel's most notable professional achievement was the series of field studies in Kuala Lumpur in 1948 which established chloramphenicol as an effective treatment for typhus and typhoid fever. In the 1950s, under Smadel's direction, WRAIR established itself as one of the première institutes for the study of infectious diseases.