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Primidone can cause drowsiness, listlessness, ataxia, visual disturbances, nystagmus, headache, and dizziness. [15] These side effects are the most common, reportedly occurring in more than 1% of users. [26] Transient nausea and vomiting are also common side effects. [27] Dupuytren's contracture of the fourth digit (ring finger)
Treatment for individual manifestations of symptoms may follow standard of care (anti-epileptic medication for seizures, physical therapy, occupational therapy, speech therapy, etc). [1] A single study points to the anti-convulsant drug primidone as an off label therapeutic. [7] Primidone is a known TRPM3 antagonist. [8]
Barbiturates slow down the central nervous system and cause tranquilizing or antiseizure effects. Phenytoin and primidone are effective antiepileptics drugs, although phenytoin can cause liver failure or have other harmful long-term effects in patients with PME. Sodium valproate is an alternative therapy for myoclonus and can be used either ...
A tremor is an involuntary, [1] somewhat rhythmic muscle contraction and relaxation involving oscillations or twitching movements of one or more body parts. It is the most common of all involuntary movements and can affect the hands, arms, eyes, face, head, vocal folds, trunk, and legs. Most tremors occur in the hands.
A few other major signs to look out for include extreme fatigue, headaches, fever, a butterfly-shaped rash across the cheeks and nose, hair loss, and Raynaud’s phenomenon (a condition in which ...
[13] [14] In people with essential tremor (ET), the head tremor can be either vertical ("yes-yes") or horizontal ("no-no") and is typically accompanied by tremors in the hands or voice. [15] Other types of tremor may also occur, including postural tremor of the outstretched arms, intention tremor of the arms, and rest tremor in the arms. [16]
Medications are used to reverse the symptoms of extrapyramidal side effects caused by antipsychotics or other drugs, by either directly or indirectly increasing dopaminergic neurotransmission. The treatment varies by the type of the EPS, but may involve anticholinergic agents such as procyclidine, benztropine, diphenhydramine, and trihexyphenidyl.
Treatment of intention tremor is very difficult. [16] The tremor may disappear for a while after a treatment has been administered and then return. This situation is addressed with a different treatment. First, individuals are asked if they use any of the drugs known to cause tremors.
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