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Ephenidine and related diarylethylamines have been studied in vitro as treatments for neurotoxic injuries, and are antagonists of the NMDA receptor (K i = 66.4 nM for ephenidine).
Abstraction of hydrogen from either the C1, C4, or C5 position of the sugar phosphate backbone of DNA by a reactive 1,4-benzenoid. The cyclization of the enediyne functional group creates a transient reactive 1,4-benzenoid diradical that acts as a nucleophile and attacks electrophiles in order to achieve a more stable form.
In man, after oral administration of 50 mg 14-C-buformin, the maximum serum concentration was 0.26-0.41 μg/mL. The buformin was eliminated with an average half-life of 2 h. About 84% of the dose administered was found excreted unchanged in the urine. [8] Buformin is not metabolized in humans.
An Abbreviated New Drug Application (ANDA) is an application for a U.S. generic drug approval for an existing licensed medication or approved drug.. The ANDA is submitted to FDA's Center for Drug Evaluation and Research, Office of Generic Drugs, which provides for the review and ultimate approval of a generic drug product.
Romania makes use of about 2,600 ambulances, and by 2015, the government is planning on purchasing an additional 1,250 ambulances. [28] Romania also has a professional emergency response unit, SMURD, which operates at major emergencies. SMURD operates independently from the regular emergency response services, but it can be dialed and asked for ...
Codeine/paracetamol, also called codeine/acetaminophen and co-codamol, is a compound analgesic, comprising codeine phosphate and paracetamol (acetaminophen). Codeine/paracetamol is used for the relief of mild to moderate pain when paracetamol or non-steroidal anti-inflammatory drugs (NSAIDs; such as ibuprofen, aspirin, and naproxen) alone do not sufficiently relieve symptoms.
Daylight saving time (DST) in Romania (locally known by "Ora de Vară") was originally introduced in 1932 (between 22 May and 2 October). Between 1933 and 1940, DST started on the first Sunday in April and ended on the first Sunday in October. DST was abandoned in 1941 and reintroduced in 1979. [3]
Romania is a popular tourist destination, with more than 15.7 million domestic and foreign tourists in 2018. Romania's tourism took a great hit during the 2020 COVID-19 pandemic, with a drop of as much as 68.7% of foreign visitors in 2020, but it's beginning to recover in 2022. [78]