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Prostate cancer is the second most common urological malignancy to be associated with paraneoplastic syndromes after renal cell carcinoma. Paraneoplastic syndromes of this nature tend to occur in the setting of late stage and aggressive tumors with poor overall outcomes (endocrine manifestations, neurological entities, dermatological conditions ...
Renal cell carcinoma is one of the cancers most strongly associated with paraneoplastic syndromes, most often due to ectopic hormone production by the tumour. The treatment for these complications of RCC is generally limited beyond treating the underlying cancer.
RCC may present with signs and symptoms caused by the substances the cancer cell produce (i.e. paraneoplastic syndromes). [citation needed] Paraneoplastic syndromes caused by kidney cancer can be broadly classified as endocrine and non-endocrine.
The most frequent, malignant, primary kidney cancer is renal cell carcinoma (RCC) - which has several subtypes: Clear cell RCC, an epithelial cell tumour of the kidney that accounts for 65-70% of all RCCs. [5] Papillary RCC, a renal tumour that accounts for 10-15% of all RCCs. Males are 1.5 times as likely to develop this type of tumour than ...
Stauffer syndrome causes abnormal liver function tests, especially those that reflect the presence of cholestasis, i.e. abnormal bile flow. Hepatosplenomegaly may also be observed. The symptoms and signs resolve if the renal cell carcinoma (or another associated tumor) is successfully ablated. It is due to release of IL-6 from cancerous cell. [1]
This branch of nephrology encompasses nephrotoxicity associated with existing and novel chemotherapeutics, kidney disease as it pertains to stem cell transplant, paraneoplastic kidney disorders, paraproteinemias (myeloma and amyloidosis), electrolyte disorders associated with cancer, and more as discussed below.
Pages in category "Paraneoplastic syndromes" The following 13 pages are in this category, out of 13 total. This list may not reflect recent changes. ...
It predisposes individuals to renal cell cancer, an association denominated hereditary leiomyomatosis and renal cell cancer. [1] [2] It is also associated with increased risk of uterine leiomyosarcoma. [3] The syndrome is caused by a mutation in the fumarate hydratase gene, which leads to an accumulation of fumarate.
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