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Summary: A 37-year-old man hospitalized for mental status changes and possible seizure developed hyperchloremic, normal anion-gap, metabolic acidosis. His medical history was significant for AIDS ...
Metabolic acidosis resolved within a few hours of administering 50 meq of a sodium bicarbonate concentration with a pH of 7.36 and bicarbonate of 24 meq/L. One day following surgery, topiramate ...
Topiramate is known to cause an imbalance in serum bicarbonate and chloride levels due to its inhibitory effect on carbonate dehydratase. Although hyperchloremic metabolic acidosis due to ...
Hyperchloremic acidosis is a hallmark of metabolic acidosis due to bicarbonate wasting and usually occurs in newborns with intestinal or renal disorders. When the anion gap is increased (≥16 ...
After receiving increased dosages of topiramate, a 37-year-old man developed hyperchloremic, normal anion-gap, metabolic acidosis, which resolved after discontinuation of the drug.
[13,14,15,16,17,18] An investigational study has linked topiramate's inhibition of carbonate dehydratase to its ability to cause hyperchloremic, normal anion-gap, metabolic acidosis secondary to ...
The patient did not require interventions for metabolic acidosis other than the discontinuation of topiramate. ... Hyperchloremic, Normal Anion-Gap, Metabolic Acidosis Due to Topiramate - Medscape ...
One of the known consequences of sodium thiosulfate administration is an elevation in the anion gap, which is explained by the dissociation of the molecule into thiosulfuric acid. Not explained is ...
The most important clinical use of the anion gap is to identify the etiology of metabolic acidosis. [] The disorders that cause metabolic acidosis fall into two categories: (1) those that cause a ...
[44,145] The normal anion gap has been historically reported to be 12 mEq/l, and values >14-15 mEq/l have been considered to indicate the presence of an increased anion gap metabolic acidosis.