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The genome organisation of HBV; the genes overlap. ORF S, in green, encodes HBsAg. HBsAg under a transmission electron microscope: the protein self assembles into virus-like particles. HBsAg (also known as the Australia antigen) is the surface antigen of the hepatitis B virus (HBV). Its presence in blood indicates existing hepatitis B infection.
HBcAg is an antigen that can be found on the surface of the nucleocapsid core (the inner most layer of the hepatitis B virus). While both HBcAg and HBeAg are made from the same open reading frame, HBcAg is not secreted as a monomer. [ 3 ] HBcAg is considered "particulate" and it does not circulate in the blood, but recent study show it can be ...
HBeAg is an antigen that can be found between the icosahedral nucleocapsid core and the lipid envelope (the outer most layer of the hepatitis b virus). However, HBeAg is considered "nonparticulate" or "secretory". [2] While both HBeAg and HBcAg are made from the same reading frame (multiple protein products can be produced from the same DNA ...
HBsAg (hepatitis B surface antigen) was the first hepatitis B virus protein to be discovered. [15] It consists of small (S), medium (M) and large (L) protein. [16] HBcAg (hepatitis B core antigen) is the main structural protein of HBV icosahedral nucleocapsid and it has function in replication of the virus. [17]
The typical seroconversion timecourse for hepatitis B. Seroconversion plays a major role in the diagnosis and treatment of hepatitis B infections. [60] As in other viral infections, seropositivity indicates that an individual has a sufficiently high concentration of antibody or antigen in the blood to be detectable by standard techniques.
820,000 resulting from hepatitis B (2019) [1] Hepatitis B is an infectious disease caused by the hepatitis B virus (HBV) that affects the liver; [1][6] it is a type of viral hepatitis. [7] It can cause both acute and chronic infection. [1] Many people have no symptoms during an initial infection. For others, symptoms may appear 30 to 180 days ...
The recombinant vaccine is based on Hepatitis B surface antigen gene inserted into yeast (Saccharomyces cerevisiae) cells which are free of any concerns associated with human blood products. [ 17 ] [ 65 ] This allows the yeast to produce only the noninfectious surface protein, without any danger of introducing actual viral DNA into the final ...
Viral hepatitis is liver inflammation due to a viral infection. [1][2] It may present in acute form as a recent infection with relatively rapid onset, or in chronic form, typically progressing from a long-lasting asymptomatic condition up to a decompensated hepatic disease and hepatocellular carcinoma (HCC). [3]
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