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Cirrhosis is a late stage of serious liver disease marked by inflammation (swelling), fibrosis (cellular hardening) and damaged membranes preventing detoxification of chemicals in the body, ending in scarring and necrosis (cell death). [11] Between 10% and 20% of heavy drinkers will develop cirrhosis of the liver (NIAAA, 1993).
Patients typically have a history of at least 10 years of heavy alcohol intake, typically 8–10 drinks per day. [3] It is usually found in association with fatty liver, an early stage of alcoholic liver disease, and may contribute to the progression of fibrosis, leading to cirrhosis. Symptoms may present acutely after a large amount of ...
Alcoholic liver disease (ALD, or alcoholic cirrhosis) develops for 10–20% of individuals who drink heavily for a decade or more. [49] Alcohol seems to injure the liver by blocking the normal metabolism of protein, fats, and carbohydrates. [50] This injury happens through the formation of acetaldehyde from alcohol.
Zieve's syndrome is an acute metabolic condition that can occur during withdrawal from prolonged heavy alcohol use. It is defined by hemolytic anemia (with spur cells and acanthocytes), hyperlipoproteinemia (excessive blood lipoprotein), jaundice (elevation of unconjugated bilirubin), and abdominal pain. [1]
Diagnosis is usually based on the history of events and physical examination. [6] Verification of events by witnesses may be useful. [ 6 ] Legally, alcohol intoxication is often defined as a blood alcohol concentration (BAC) of greater than 5.4–17.4 mmol/L (25–80 mg/dL or 0.025–0.080%).
The concept of "harmful use" (as opposed to "abuse") was introduced in 1992's ICD-10 to minimize underreporting of damage in the absence of dependence. [116] The term "alcoholism" was removed from ICD between ICD-8/ICDA-8 and ICD-9. [120] ICD-11: Episode of harmful use of alcohol, Harmful pattern of use of alcohol, or Alcohol dependence
For reference, experts recommend no more than one drink a day for females and no more than two drinks a day for males. One drink is defined as 1.5 ounces of liquor, 12 ounces of beer or 5 ounces ...
ICD-10 is the 10th revision of the International Classification of Diseases (ICD), a medical classification list by the World Health Organization (WHO). It contains codes for diseases, signs and symptoms, abnormal findings, complaints, social circumstances, and external causes of injury or diseases. [1]