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  2. von Willebrand disease - Wikipedia

    en.wikipedia.org/wiki/Von_Willebrand_disease

    Von Willebrand disease (VWD) is the most common hereditary blood-clotting disorder in humans. An acquired form can sometimes result from other medical conditions. [1] It arises from a deficiency in the quality or quantity of von Willebrand factor (VWF), a multimeric protein that is required for platelet adhesion. It is known to affect several ...

  3. Erik Adolf von Willebrand - Wikipedia

    en.wikipedia.org/wiki/Erik_Adolf_von_Willebrand

    Erik Adolf von Willebrand (1 February 1870 – 12 September 1949) was a Finnish physician who made major contributions to hematology. ... The bleeding time ...

  4. Bleeding time - Wikipedia

    en.wikipedia.org/wiki/Bleeding_time

    Bleeding time may be affected by platelet function, certain vascular disorders and von Willebrand Disease—not by other coagulation factors such as haemophilia.Diseases that may cause prolonged bleeding time include thrombocytopenia, disseminated intravascular coagulation (DIC), Bernard-Soulier disease, and Glanzmann's thrombasthenia.

  5. A vet’s guide to Von Willebrand Disease in dogs - AOL

    www.aol.com/vet-guide-von-willebrand-disease...

    Von Willebrand Disease in dogs is a complex clotting disorder that can vary in symptoms and the risk of genetic inheritance. ... A Buccal Mucosal Bleeding Time test can help to confirm slow ...

  6. von Willebrand factor - Wikipedia

    en.wikipedia.org/wiki/Von_Willebrand_factor

    Von Willebrand factor (VWF) (German: [fɔn ˈvɪləbʁant]) is a blood glycoprotein that promotes hemostasis, specifically, platelet adhesion.It is deficient and/or defective in von Willebrand disease and is involved in many other diseases, including thrombotic thrombocytopenic purpura, Heyde's syndrome, and possibly hemolytic–uremic syndrome. [5]

  7. Ristocetin-induced platelet aggregation - Wikipedia

    en.wikipedia.org/wiki/Ristocetin-induced...

    In an unknown fashion, the antibiotic ristocetin causes von Willebrand factor to bind the platelet receptor glycoprotein Ib (GpIb), so when ristocetin is added to normal blood, it causes agglutination of fixed platelets or initiates the initial agglutination phase of aggregation of live platelets. [citation needed]

  8. Bleeding diathesis - Wikipedia

    en.wikipedia.org/wiki/Bleeding_diathesis

    Soft tissue bleeding, e.g. deep-muscle bleeding, leading to swelling, numbness or pain of a limb. Hemophilia [7] Von Willebrand disease [8] Joint damage, potentially with severe pain and even destruction of the joint and development of arthritis: Hemophilia [7] Von Willebrand disease [8] Retinal bleeding: Acute leukemia [5]

  9. Bernard–Soulier syndrome - Wikipedia

    en.wikipedia.org/wiki/Bernard–Soulier_syndrome

    Bernard–Soulier syndrome (BSS) is a rare autosomal recessive bleeding disorder that is caused by a deficiency of the glycoprotein Ib-IX-V complex (GPIb-IX-V), the receptor for von Willebrand factor. [5] The incidence of BSS is estimated to be less than 1 case per million persons, based on cases reported from Europe, North America, and Japan.

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