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Similarly, gene activity in the human brain is better understood through examination of the brains of mice by the Seattle-based Allen Institute for Brain Science (see link below), yielding the freely available Allen Brain Atlas. [3] This type of study is related to comparative cognition, but better classified as one of comparative genomics.
For instance, humanized mice have been utilized to study human-tropic pathogens, liver cancer models, and the comparison of mouse models to human diseases NSG mice engrafted with PBMCs and administered with myelin antigens in Freund's adjuvant, and antigen-pulsed autologous dendritic cells have been used to study multiple sclerosis. [33]
The Allen Human Brain Atlas was made public in May 2010. It was the first anatomically and genomically comprehensive three-dimensional human brain map. [4] The atlas was created to enhance research in many neuroscience research fields including neuropharmacology, human brain imaging, human genetics, neuroanatomy, genomics and more.
And of those 3 billion base pairs, only a tiny amount are unique to us, making us about 99.9% genetically similar to the next human. ... mice are 85 percent similar to humans. For non-coding genes ...
Despite superficial differences, especially in size and weight, the mouse brain and its function can serve as a powerful animal model for study of human brain diseases or mental disorders (see e.g. Reeler, Chakragati mouse). This is because the genes responsible for building and operating both mouse and human brain are 90% identical. [4]
With so much of the genome conserved across species, it is relatively impressive that the differences between humans and mice can be accounted for in approximately six thousand genes (of ~30,000 total). Scientists have been able to take advantage of these similarities in generating experimental and predictive models of human disease.
Rodents, most especially mice, are excellent animal models of autism because they have similar social relationships and neuroscience. When exposed to prenatal valproate (VPA) during pregnancy, the mice are born with basic deformities and the developmental delays seen symptomatically in humans 5. This is all comparable and easier to study since ...
Thus, large whales have very small brains compared to their weight, and small rodents like mice have a relatively large brain, giving a brain-to-body mass ratio similar to humans. [4] One explanation could be that as an animal's brain gets larger, the size of the neural cells remains the same, and more nerve cells will cause the brain to ...