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3589 16156 Ensembl ENSG00000095752 ENSMUSG00000004371 UniProt P20809 P47873 RefSeq (mRNA) NM_001267718 NM_000641 NM_008350 NM_001290423 RefSeq (protein) NP_000632 NP_001254647 NP_001277352 NP_032376 Location (UCSC) Chr 19: 55.36 – 55.37 Mb Chr 7: 4.78 – 4.79 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interleukin 11 (IL-11 or adipogenesis inhibitory factor) is a protein that ...
Interleukin 11 (IL-11) is a secreted protein that stimulates megakaryocytopoiesis, initially thought to lead to an increased production of platelets (it has since been shown to be redundant to normal platelet formation), as well as activating osteoclasts, inhibiting epithelial cell proliferation and apoptosis, and inhibiting macrophage mediator ...
T h 2 cells and ILC2 cells secrete IL-4, IL-5 and IL-13. [1] [3] IL-4 further drives CD4+ T cell differentiation towards the T h 2 subtype and induces isotype switching to IgE in B cells. IL-4 and IL-13 stimulate trafficking of eosinophils to the site of inflammation, while IL-5 promotes both eosinophil trafficking and production. [2]
In fact, eccentric exercise may result in a delayed peak and a much slower decrease of plasma IL-6 during recovery. [23] Anti-IL-6 therapies should therefore take into consideration the (beneficial) anti-inflammatory effects of myokines generally, including the now-established multiple benefits of muscle-derived Interleukin 6. [23]
Loss-of-function mutations of IL-1Ra can develop fatal systemic inflammatory response syndrome. Another example is the inability of the anti-inflammatory cytokines, such as IL-10, to signal through its receptor. That, again, can lead to systemic inflammation and severe inflammatory bowel disease (IBD). This shows that even single-cytokine ...
MIP-1γ is another macrophage inflammatory protein and according to the new nomenclature is named CCL9. [3] It is produced mainly by follicle-associated epithelial cells and is responsible for chemotaxis of dendritic cells and macrophages into Peyer's patches in gut through binding of CCR1. [11] MIP-1δ or MIP-5 (CCL15) binds also CCR1 and CCR3 ...
Interleukin 11 receptor, alpha subunit is a subunit of the interleukin 11 receptor. IL11RA is its human gene. [5] Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which ...
IL-12 binds to the IL-12 receptor, which is a heterodimeric receptor formed by IL-12Rβ1 and IL-12Rβ2. [6] IL-12Rβ2 is considered to play a key role in IL-12 function, since it is found on activated T cells and is stimulated by cytokines that promote Th1 cells development and inhibited by those that promote Th2 cells development.