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Alternatively spliced transcript variants encoding different isoforms have been identified for HOXC6. Transcript variant two includes the shared exon, and transcript variant one includes only gene-specific exons. [7] HOXC6 plays a role in lymphoma. The HOXC6 isoform, HOXC6-2 is an active carcinogenic for gastric cancer.
HoxC6 was found to play an important role in gastrulation in the vertebrate Xenopus. However, gastrulation was also a target in the Drosophila Antp gene. The anterior–posterior pattern mechanism is highly conserved in these genes, as its function in Xenopus is clear, but it is unclear why it would be a target in Drosophila .
Hox genes, a subset of homeobox genes, are a group of related genes that specify regions of the body plan of an embryo along the head-tail axis of animals. Hox proteins encode and specify the characteristics of 'position', ensuring that the correct structures form in the correct places of the body.
Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants have been described for HOXC5. The transcript variant which includes the shared exon apparently doesn't encode a protein.
What is the latest COVID variant, LB.1? LB.1 is the third most common COVID-19 variant in the U.S. right now, per CDC data. It’s a descendant of JN.1, along with common variants KP.2 and KP.3, ...
BA.2.86 features more than 30 mutations compared to omicron XBB.1.5, which was the dominant variant for most of 2023 — it's also the strain targeted in the updated COVID-19 vaccine.
The JN.1, which is closely related to the BA.2.86 variant that the CDC has tracked since August, was first detected in September 2023. But it didn’t become the main strain until late December ...
15423 Ensembl ENSG00000198353 ENSMUSG00000075394 UniProt P09017 Q86TF7 Q08624 RefSeq (mRNA) NM_153633 NM_014620 NM_013553 RefSeq (protein) NP_055435 NP_705897 NP_055435.2 NP_705897.1 NP_038581 Location (UCSC) Chr 12: 54.02 – 54.06 Mb Chr 15: 102.93 – 102.95 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein Hox-C4 is a protein that in humans is encoded by the HOXC4 ...