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The antidotes for ethylene glycol poisoning are ethanol and fomepizole. This antidotal treatment forms the mainstay of management of ethylene glycol poisoning. The toxicity of ethylene glycol comes from its metabolism to glycolic acid and oxalic acid. The goal of pharmacotherapy is to prevent the formation of these metabolites.
Fomepizole is used to treat ethylene glycol and methanol poisoning. It acts to inhibit the breakdown of these toxins into their active toxic metabolites. Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase, [6] found in the liver. This enzyme plays a key role in the metabolism of ethylene glycol, and of methanol.
The snacks were contaminated with ethylene glycol, probably originating from contamined propylene glycol. All products made by Bassar were recalled on the 7th of September. [113] 2024 – Applesauce products containing cinnamon were found to contain lead chromate, leading to reports of child lead poisoning across the United States. The source ...
At 9:42 a.m. on the morning of Julie’s death, someone searched the internet on the family’s desktop computer for diminished consciousness from ethylene glycol poisoning, Jambois said. The two ...
Ethylene glycol is widely used to inhibit the formation of natural gas clathrates (hydrates) in long multiphase pipelines that convey natural gas from remote gas fields to a gas processing facility. Ethylene glycol can be recovered from the natural gas and reused as an inhibitor after purification treatment that removes water and inorganic salts.
The major cause of ethylene glycol toxicity is the accumulation of glycolic acid in the body, [18] but accumulation of calcium oxalate crystals in the kidneys can also lead to acute kidney failure. [17] In the case of DEG, calcium oxalate crystal are not deposited in the kidneys, implying that ethylene glycol is not on the DEG metabolic pathway.
Ethylene glycol “is a colorless, odorless, sweet-tasting compound used in consumer products including antifreeze,” the affidavit says. Ingesting it can be fatal.
New details about a study that warned against black plastic spatulas and other kitchen tools have come out. (Getty Creative) (Анатолий Тушенцов via Getty Images)